Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 603643..604442 Replicon chromosome
Accession NZ_CP097721
Organism Escherichia coli strain MS1665

Toxin (Protein)


Gene name yhaV Uniprot ID U9XVR9
Locus tag M9O79_RS02950 Protein ID WP_000347267.1
Coordinates 603643..604107 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1EB98
Locus tag M9O79_RS02955 Protein ID WP_001307405.1
Coordinates 604107..604442 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O79_RS02920 (598644) 598644..599078 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
M9O79_RS02925 (599096) 599096..599974 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
M9O79_RS02930 (599964) 599964..600743 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
M9O79_RS02935 (600754) 600754..601227 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
M9O79_RS02940 (601250) 601250..602530 - 1281 WP_000681933.1 tagatose-bisphosphate aldolase subunit KbaZ -
M9O79_RS02945 (602779) 602779..603588 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
M9O79_RS02950 (603643) 603643..604107 - 465 WP_000347267.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
M9O79_RS02955 (604107) 604107..604442 - 336 WP_001307405.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
M9O79_RS02960 (604591) 604591..606162 - 1572 WP_001273741.1 galactarate dehydratase -
M9O79_RS02965 (606537) 606537..607871 + 1335 WP_000599636.1 galactarate/glucarate/glycerate transporter GarP -
M9O79_RS02970 (607887) 607887..608657 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17807.17 Da        Isoelectric Point: 9.4947

>T246150 WP_000347267.1 NZ_CP097721:c604107-603643 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12358.94 Da        Isoelectric Point: 4.8616

>AT246150 WP_001307405.1 NZ_CP097721:c604442-604107 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGQDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XTR4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0XVC7

References