Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4954006..4954608 Replicon chromosome
Accession NZ_CP097719
Organism Escherichia coli strain MS1679

Toxin (Protein)


Gene name higB Uniprot ID U9XIS6
Locus tag M9O74_RS24340 Protein ID WP_000897305.1
Coordinates 4954297..4954608 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M9O74_RS24335 Protein ID WP_000356397.1
Coordinates 4954006..4954296 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O74_RS24315 (4950508) 4950508..4951410 + 903 WP_000331377.1 formate dehydrogenase O subunit beta -
M9O74_RS24320 (4951407) 4951407..4952042 + 636 WP_000829013.1 formate dehydrogenase cytochrome b556 subunit -
M9O74_RS24325 (4952039) 4952039..4952968 + 930 WP_039025804.1 formate dehydrogenase accessory protein FdhE -
M9O74_RS24330 (4953183) 4953183..4953401 - 219 WP_001295676.1 CopG family transcriptional regulator -
M9O74_RS24335 (4954006) 4954006..4954296 - 291 WP_000356397.1 NadS family protein Antitoxin
M9O74_RS24340 (4954297) 4954297..4954608 - 312 WP_000897305.1 hypothetical protein Toxin
M9O74_RS24345 (4954837) 4954837..4955745 + 909 WP_001318161.1 alpha/beta hydrolase -
M9O74_RS24350 (4955809) 4955809..4956750 - 942 WP_001297068.1 fatty acid biosynthesis protein FabY -
M9O74_RS24355 (4956795) 4956795..4957232 - 438 WP_000560983.1 D-aminoacyl-tRNA deacylase -
M9O74_RS24360 (4957229) 4957229..4958101 - 873 WP_000920762.1 virulence factor BrkB family protein -
M9O74_RS24365 (4958095) 4958095..4958694 - 600 WP_001315111.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12190.19 Da        Isoelectric Point: 9.7791

>T246141 WP_000897305.1 NZ_CP097719:c4954608-4954297 [Escherichia coli]
MLFIETEIFTEDVQKLLTDDEFSRFQFFLALNPDYGEVIPETGGLRKVRWVSGGKGKRAGVRVIYFHQVKHYEIRLLLIY
RKGIKDDLSPQEKAMLRLLNTRW

Download         Length: 312 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10846.43 Da        Isoelectric Point: 10.8907

>AT246141 WP_000356397.1 NZ_CP097719:c4954296-4954006 [Escherichia coli]
MDKALFERLTHSMAQMNEIIEGTRQPSRTFEVDAMKIKEIRRASGLSQSKFADLISVSVDTLRNWEQGRRSPTGPAKALL
RAIANDPQHVLQALNR

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y7I7

Antitoxin

Source ID Structure

References