Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 639008..639807 Replicon chromosome
Accession NZ_CP097719
Organism Escherichia coli strain MS1679

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag M9O74_RS03145 Protein ID WP_000347251.1
Coordinates 639008..639472 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag M9O74_RS03150 Protein ID WP_001296435.1
Coordinates 639472..639807 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O74_RS03115 (634009) 634009..634443 - 435 WP_000948823.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
M9O74_RS03120 (634461) 634461..635339 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
M9O74_RS03125 (635329) 635329..636108 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
M9O74_RS03130 (636119) 636119..636592 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
M9O74_RS03135 (636615) 636615..637895 - 1281 WP_000681938.1 tagatose-bisphosphate aldolase subunit KbaZ -
M9O74_RS03140 (638144) 638144..638953 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
M9O74_RS03145 (639008) 639008..639472 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
M9O74_RS03150 (639472) 639472..639807 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
M9O74_RS03155 (639956) 639956..641527 - 1572 WP_001273939.1 galactarate dehydratase -
M9O74_RS03160 (641902) 641902..643236 + 1335 WP_000979025.1 galactarate/glucarate/glycerate transporter GarP -
M9O74_RS03165 (643252) 643252..644022 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T246121 WP_000347251.1 NZ_CP097719:c639472-639008 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT246121 WP_001296435.1 NZ_CP097719:c639807-639472 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References