Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-agrB/SymE(toxin)
Location 4342333..4342745 Replicon chromosome
Accession NZ_CP097716
Organism Escherichia coli strain MS1718

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag M9O77_RS20730 Protein ID WP_000132601.1
Coordinates 4342404..4342745 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name agrB
Locus tag -
Coordinates 4342333..4342409 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O77_RS20720 (4339196) 4339196..4340785 + 1590 WP_001063200.1 type I restriction-modification system methyltransferase -
M9O77_RS20725 (4340782) 4340782..4342176 + 1395 WP_001272445.1 type I restriction-modification system specificity subunit -
- (4342333) 4342333..4342409 - 77 NuclAT_7 - Antitoxin
- (4342333) 4342333..4342409 - 77 NuclAT_7 - Antitoxin
- (4342333) 4342333..4342409 - 77 NuclAT_7 - Antitoxin
- (4342333) 4342333..4342409 - 77 NuclAT_7 - Antitoxin
- (4342333) 4342333..4342409 - 77 NuclAT_8 - Antitoxin
- (4342333) 4342333..4342409 - 77 NuclAT_8 - Antitoxin
- (4342333) 4342333..4342409 - 77 NuclAT_8 - Antitoxin
- (4342333) 4342333..4342409 - 77 NuclAT_8 - Antitoxin
M9O77_RS20730 (4342404) 4342404..4342745 + 342 WP_000132601.1 endoribonuclease SymE Toxin
M9O77_RS20735 (4342907) 4342907..4344286 + 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
M9O77_RS20740 (4344286) 4344286..4345332 + 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T246102 WP_000132601.1 NZ_CP097716:4342404-4342745 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

Antitoxin


Download         Length: 77 bp

>AT246102 NZ_CP097716:c4342409-4342333 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References