Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 633181..633980 Replicon chromosome
Accession NZ_CP097716
Organism Escherichia coli strain MS1718

Toxin (Protein)


Gene name yhaV Uniprot ID V0SSH7
Locus tag M9O77_RS03020 Protein ID WP_000347273.1
Coordinates 633181..633645 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID D6JF08
Locus tag M9O77_RS03025 Protein ID WP_001308975.1
Coordinates 633645..633980 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O77_RS02990 (628182) 628182..628616 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
M9O77_RS02995 (628634) 628634..629512 - 879 WP_001298314.1 PTS N-acetylgalactosamine transporter subunit IID -
M9O77_RS03000 (629502) 629502..630281 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
M9O77_RS03005 (630292) 630292..630765 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
M9O77_RS03010 (630788) 630788..632068 - 1281 WP_023908831.1 tagatose-bisphosphate aldolase subunit KbaZ -
M9O77_RS03015 (632317) 632317..633126 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
M9O77_RS03020 (633181) 633181..633645 - 465 WP_000347273.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
M9O77_RS03025 (633645) 633645..633980 - 336 WP_001308975.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
M9O77_RS03030 (634129) 634129..635700 - 1572 WP_077516436.1 galactarate dehydratase -
M9O77_RS03035 (636075) 636075..637409 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
M9O77_RS03040 (637425) 637425..638195 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17836.25 Da        Isoelectric Point: 9.6924

>T246084 WP_000347273.1 NZ_CP097716:c633645-633181 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVETLKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWETLTRETEETH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12343.97 Da        Isoelectric Point: 4.8616

>AT246084 WP_001308975.1 NZ_CP097716:c633980-633645 [Escherichia coli]
MPANARSHAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFNIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SSH7

Antitoxin

Source ID Structure
AlphaFold DB D6JF08

References