Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 4030458..4030867 Replicon chromosome
Accession NZ_CP097711
Organism Escherichia coli strain MS1737

Toxin (Protein)


Gene name symE Uniprot ID -
Locus tag M9O76_RS19585 Protein ID WP_001534835.1
Coordinates 4030529..4030867 (+) Length 113 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 4030458..4030534 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O76_RS19575 (4025646) 4025646..4026956 + 1311 WP_001534837.1 restriction endonuclease subunit S -
M9O76_RS19580 (4027051) 4027051..4030314 + 3264 WP_267326316.1 HsdR family type I site-specific deoxyribonuclease -
- (4030458) 4030458..4030534 - 77 NuclAT_11 - Antitoxin
- (4030458) 4030458..4030534 - 77 NuclAT_11 - Antitoxin
- (4030458) 4030458..4030534 - 77 NuclAT_11 - Antitoxin
- (4030458) 4030458..4030534 - 77 NuclAT_11 - Antitoxin
- (4030458) 4030458..4030534 - 77 NuclAT_12 - Antitoxin
- (4030458) 4030458..4030534 - 77 NuclAT_12 - Antitoxin
- (4030458) 4030458..4030534 - 77 NuclAT_12 - Antitoxin
- (4030458) 4030458..4030534 - 77 NuclAT_12 - Antitoxin
M9O76_RS19585 (4030529) 4030529..4030867 + 339 WP_001534835.1 endoribonuclease SymE Toxin
M9O76_RS19590 (4030955) 4030955..4031089 - 135 WP_001314403.1 hypothetical protein -
M9O76_RS19595 (4031251) 4031251..4031559 + 309 Protein_3838 winged helix-turn-helix domain-containing protein -
M9O76_RS19600 (4031551) 4031551..4032471 - 921 WP_000181193.1 Rpn family recombination-promoting nuclease/putative transposase -
M9O76_RS19605 (4032656) 4032656..4033936 + 1281 WP_001535800.1 DUF445 domain-containing protein -
M9O76_RS19610 (4034052) 4034052..4035203 + 1152 WP_001338076.1 double-cubane-cluster-containing anaerobic reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 12310.04 Da        Isoelectric Point: 7.8226

>T246066 WP_001534835.1 NZ_CP097711:4030529-4030867 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRQLTVSYASRYPDYNRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQDFIGVISNKTPR

Download         Length: 339 bp

Antitoxin


Download         Length: 77 bp

>AT246066 NZ_CP097711:c4030534-4030458 [Escherichia coli]
AGTCATAACTGCTATTCCCTATAAATAGTGATTGTGATGAGCGGTGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References