Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2440510..2441072 Replicon chromosome
Accession NZ_CP097711
Organism Escherichia coli strain MS1737

Toxin (Protein)


Gene name higB Uniprot ID S1Q1V8
Locus tag M9O76_RS11770 Protein ID WP_000605675.1
Coordinates 2440510..2440788 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID S1PAQ1
Locus tag M9O76_RS11775 Protein ID WP_000781370.1
Coordinates 2440788..2441072 (+) Length 95 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O76_RS11745 (2436098) 2436098..2436529 - 432 WP_000152305.1 peroxiredoxin OsmC -
M9O76_RS11750 (2436874) 2436874..2437089 + 216 WP_000495766.1 biofilm-dependent modulation protein -
M9O76_RS11755 (2437191) 2437191..2437328 + 138 WP_000841554.1 stationary-phase-induced ribosome-associated protein -
M9O76_RS11760 (2437484) 2437484..2439181 + 1698 WP_000433462.1 malate dehydrogenase -
M9O76_RS11765 (2439314) 2439314..2440324 + 1011 WP_000642412.1 alcohol dehydrogenase AdhP -
M9O76_RS11770 (2440510) 2440510..2440788 + 279 WP_000605675.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M9O76_RS11775 (2440788) 2440788..2441072 + 285 WP_000781370.1 HigA family addiction module antitoxin Antitoxin
M9O76_RS11780 (2441301) 2441301..2441954 - 654 WP_000045647.1 formate dehydrogenase-N subunit gamma -
M9O76_RS11785 (2441947) 2441947..2442831 - 885 WP_001240584.1 formate dehydrogenase N subunit beta -
M9O76_RS11790 (2442844) 2442844..2445891 - 3048 WP_077634457.1 formate dehydrogenase-N subunit alpha -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(4-92)

Antitoxin

(1-88)


Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10537.16 Da        Isoelectric Point: 7.3206

>T246062 WP_000605675.1 NZ_CP097711:2440510-2440788 [Escherichia coli]
MIMNFRHKGLRDLFLLGKTSGVIPTQVKRLRHRLAVIDAACCLADIDMPGYRLHPLSGDRDGIWAISVSGNWRITFEFVN
GDAYILDYEDYH

Download         Length: 279 bp


Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10401.08 Da        Isoelectric Point: 8.8567

>AT246062 WP_000781370.1 NZ_CP097711:2440788-2441072 [Escherichia coli]
MKMANHPRPGDIIQESLDELNVSLREFARAMEIAPSTASRLLTGKAALTPEMAIKLSVVIGSSPQMWLNLQNAWSLAEAE
KTVDVSRLRRLVTQ

Download         Length: 285 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB S1Q1V8


Antitoxin

Source ID Structure
PDB 2ICT
PDB 2ICP
AlphaFold DB A0A829CUG6

References