Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1209559..1210286 Replicon chromosome
Accession NZ_CP097711
Organism Escherichia coli strain MS1737

Toxin (Protein)


Gene name higB Uniprot ID Q3YYE6
Locus tag M9O76_RS05870 Protein ID WP_000547563.1
Coordinates 1209559..1209870 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M9O76_RS05875 Protein ID WP_000126304.1
Coordinates 1209867..1210286 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9O76_RS05840 (1204703) 1204703..1206412 + 1710 WP_001288123.1 formate hydrogenlyase subunit HycE -
M9O76_RS05845 (1206422) 1206422..1206964 + 543 WP_000493800.1 formate hydrogenlyase subunit HycF -
M9O76_RS05850 (1206964) 1206964..1207731 + 768 WP_000067399.1 formate hydrogenlyase subunit HycG -
M9O76_RS05855 (1207728) 1207728..1208138 + 411 WP_001291918.1 formate hydrogenlyase assembly protein HycH -
M9O76_RS05860 (1208131) 1208131..1208598 + 468 WP_000132955.1 hydrogenase maturation peptidase HycI -
M9O76_RS05865 (1208641) 1208641..1209396 + 756 WP_087904422.1 hypothetical protein -
M9O76_RS05870 (1209559) 1209559..1209870 + 312 WP_000547563.1 type II toxin-antitoxin system HigB family toxin Toxin
M9O76_RS05875 (1209867) 1209867..1210286 + 420 WP_000126304.1 helix-turn-helix domain-containing protein Antitoxin
M9O76_RS05880 (1210378) 1210378..1210806 - 429 WP_000536066.1 DUF4259 domain-containing protein -
M9O76_RS05885 (1211191) 1211191..1211718 + 528 WP_001078777.1 electron transport protein HydN -
M9O76_RS05890 (1211871) 1211871..1214123 + 2253 WP_001535518.1 carbamoyltransferase HypF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(22-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(85-138)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12398.11 Da        Isoelectric Point: 9.7105

>T246055 WP_000547563.1 NZ_CP097711:1209559-1209870 [Escherichia coli]
MHIISKAPFEESARKYPNDALALQALYRVIKETDFSTPEEMRTAFPNLDNFKYRNKWYVLDVGGNNLRVIAYINFVNKRF
FVKHITNHAEYDKLTRYYRENKE

Download         Length: 312 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15474.50 Da        Isoelectric Point: 4.4596

>AT246055 WP_000126304.1 NZ_CP097711:1209867-1210286 [Escherichia coli]
MTANAVRAVKATRELVNAVPFLGGSDSEDDYREALELVEYLIEEDDTNPLIDFLTSRIAEYENNNEKFAEFDKAVAAMPV
GVALLRTLIDQHNLTYADLKNEIGSKSLVSQILSGQRSLTISHIKALSARFGVKPEWFL

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QA22

Antitoxin

Source ID Structure

References