Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 5961069..5961664 Replicon chromosome
Accession NZ_CP097709
Organism Pseudomonas aeruginosa strain PA-1

Toxin (Protein)


Gene name higB Uniprot ID A0A241XLJ5
Locus tag M8341_RS28080 Protein ID WP_003117425.1
Coordinates 5961386..5961664 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M8341_RS28075 Protein ID WP_003113527.1
Coordinates 5961069..5961374 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8341_RS28040 (M8341_28035) 5956208..5957056 + 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
M8341_RS28050 (M8341_28045) 5957223..5958164 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
M8341_RS28055 (M8341_28050) 5958281..5958895 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
M8341_RS28060 (M8341_28055) 5958937..5959521 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
M8341_RS28065 (M8341_28060) 5959562..5960662 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
M8341_RS28075 (M8341_28070) 5961069..5961374 - 306 WP_003113527.1 HigA family addiction module antitoxin Antitoxin
M8341_RS28080 (M8341_28075) 5961386..5961664 - 279 WP_003117425.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8341_RS28085 (M8341_28080) 5961717..5961845 - 129 Protein_5556 integrase -
M8341_RS28090 (M8341_28085) 5961993..5964221 + 2229 WP_003113525.1 TonB-dependent receptor -
M8341_RS28095 (M8341_28090) 5964291..5964938 - 648 WP_003095021.1 carbonate dehydratase -
M8341_RS28100 (M8341_28095) 5965000..5966238 - 1239 WP_003113524.1 dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-69)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10701.28 Da        Isoelectric Point: 8.5576

>T246044 WP_003117425.1 NZ_CP097709:c5961664-5961386 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAARELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11247.81 Da        Isoelectric Point: 5.0747

>AT246044 WP_003113527.1 NZ_CP097709:c5961374-5961069 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMEFDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241XLJ5

Antitoxin

Source ID Structure

References