Detailed information of TA system TA245995

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 70291..70717
• Replicon: plasmid unnamed1
• Accession: NZ_CP097695
• Organism: Klebsiella pneumoniae strain IR12182_1

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: M3X85_RS27460
• Protein ID: WP_001372321.1
• Coordinates: 70592..70717 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	70291..70515 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M3X85_RS27425 (65401)	65401..65856	-	456	Protein_93	hypothetical protein	-
M3X85_RS27430 (66158)	66158..66685	+	528	WP_000290834.1	single-stranded DNA-binding protein	-
M3X85_RS27435 (66743)	66743..66976	+	234	WP_000006003.1	DUF905 family protein	-
M3X85_RS27440 (67037)	67037..69060	+	2024	Protein_96	ParB/RepB/Spo0J family partition protein	-
M3X85_RS27445 (69129)	69129..69563	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
M3X85_RS27450 (69560)	69560..70279	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
- (70291)	70291..70515	+	225	NuclAT_0	-	Antitoxin
- (70291)	70291..70515	+	225	NuclAT_0	-	Antitoxin
- (70291)	70291..70515	+	225	NuclAT_0	-	Antitoxin
- (70291)	70291..70515	+	225	NuclAT_0	-	Antitoxin
M3X85_RS27455 (70501)	70501..70650	+	150	Protein_99	plasmid maintenance protein Mok	-
M3X85_RS27460 (70592)	70592..70717	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
M3X85_RS27465 (71036)	71036..71332	-	297	Protein_101	hypothetical protein	-
M3X85_RS27470 (71632)	71632..71928	+	297	WP_001272251.1	hypothetical protein	-
M3X85_RS27475 (72039)	72039..72860	+	822	WP_001234445.1	DUF932 domain-containing protein	-
M3X85_RS27480 (73157)	73157..73804	-	648	WP_015059008.1	transglycosylase SLT domain-containing protein	-
M3X85_RS27485 (74081)	74081..74464	+	384	WP_000124981.1	conjugal transfer relaxosome DNA-binding protein TraM	-
M3X85_RS27490 (74655)	74655..75341	+	687	WP_015059009.1	PAS domain-containing protein	-
M3X85_RS27495 (75435)	75435..75662	+	228	WP_001254386.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	blaKPC-2 / rmtB / blaTEM-1B	-	1..131777	131777

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T245995 WP_001372321.1 NZ_CP097695:70592-70717 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

Antitoxin

Nucleotide

• Length: 225 bp

>AT245995 NZ_CP097695:70291-70515 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin