Detailed information of TA system TA024598

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 692793..693392
• Replicon: chromosome
• Accession: NC_013939
• Organism: Deferribacter desulfuricans SSM1

Toxin (Protein)

• Gene name: graT
• Uniprot ID: D3PC73
• Locus tag: DEFDS_RS03605
• Protein ID: WP_013007444.1
• Coordinates: 692793..693077 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: DEFDS_RS03610
• Protein ID: WP_013007445.1
• Coordinates: 693093..693392 (+)
• Length: 100 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DEFDS_RS03570	688464..688889	-	426	WP_013007437.1	helix-turn-helix domain-containing protein	-
DEFDS_RS03575	689077..690378	-	1302	WP_013007438.1	helix-turn-helix domain-containing protein	-
DEFDS_RS03580	690498..690812	-	315	WP_013007439.1	hypothetical protein	-
DEFDS_RS03585	690942..691220	+	279	WP_013007440.1	hypothetical protein	-
DEFDS_RS03590	691236..691664	-	429	WP_013007441.1	hypothetical protein	-
DEFDS_RS03595	691666..692669	-	1004	Protein_702	integrase domain-containing protein	-
DEFDS_RS03605	692793..693077	+	285	WP_013007444.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DEFDS_RS03610	693093..693392	+	300	WP_013007445.1	HigA family addiction module antidote protein	Antitoxin
DEFDS_RS03615	694089..694412	+	324	WP_013007446.1	hypothetical protein	-
DEFDS_RS03620	694425..694604	-	180	WP_041223596.1	hypothetical protein	-
DEFDS_RS03625	694582..695385	-	804	WP_013007447.1	ParM/StbA family protein	-
DEFDS_RS03630	695803..697932	-	2130	WP_013007448.1	LssY C-terminal domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-1 (1-94)

Antitoxin

• Cro/C1-type helix-turn-helix domain (21-70)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11234.08 Da
• Isoelectric Point: 9.9334

>T24598 WP_013007444.1 NC_013939:692793-693077 [Deferribacter desulfuricans SSM1]
MIKNFKDKETERLFKTGISKKLPSHIIKTAIRKLDMLDAAYEIKDLEIPPGNRLERLKGNLKEYYSIRINDQYRIIFKFE
QGNAYDVQIIDYHK

Nucleotide

• Length: 285 bp

>T24598 NC_013939:692793-693077 [Deferribacter desulfuricans SSM1]
ATGATAAAAAATTTTAAGGATAAGGAAACGGAAAGACTGTTTAAAACAGGTATCAGTAAAAAGCTTCCATCACATATTAT
TAAAACTGCTATTAGGAAACTAGATATGTTAGATGCAGCTTATGAAATAAAAGATTTAGAAATACCTCCAGGAAACAGAT
TAGAAAGGCTAAAAGGTAATTTAAAAGAATACTATAGTATAAGAATAAATGATCAATATCGAATAATTTTTAAATTTGAG
CAGGGAAATGCTTATGATGTTCAAATTATAGATTATCATAAATAA

Antitoxin

Protein

• Length: 100 a.a.
• Molecular weight: 11470.48 Da
• Isoelectric Point: 9.6768

>AT24598 WP_013007445.1 NC_013939:693093-693392 [Deferribacter desulfuricans SSM1]
MPFILRRMPTHPGEILREEFMIPYGINQVKLAKDLGVTYRTINEIVNEKRSISPEMALKLAKYFGTTPEFWLGLQMKYDL
YKASKKADIDQITPLVHGN

Nucleotide

• Length: 300 bp

>AT24598 NC_013939:693093-693392 [Deferribacter desulfuricans SSM1]
ATGCCATTTATATTAAGAAGGATGCCTACACATCCAGGAGAAATACTTAGAGAAGAGTTTATGATTCCTTATGGGATAAA
TCAGGTTAAACTGGCTAAAGATTTAGGTGTGACATATAGAACGATTAACGAAATTGTAAATGAGAAAAGATCTATAAGCC
CTGAAATGGCATTGAAGTTGGCTAAGTATTTTGGGACAACTCCAGAGTTTTGGTTGGGTTTGCAAATGAAATATGATTTA
TACAAAGCCAGCAAGAAGGCTGATATAGATCAGATCACACCTCTTGTACATGGTAATTAA

Structures

Toxin

• AlphaFold DB: D3PC73