245933

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 777783..778558 Replicon chromosome
Accession NZ_CP097688
Organism Klebsiella pneumoniae strain IR12079_1

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag M3X89_RS03955 Protein ID WP_004150910.1
Coordinates 778073..778558 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag M3X89_RS03950 Protein ID WP_004150912.1
Coordinates 777783..778076 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X89_RS03930 (M3X89_03930) 772991..773593 - 603 WP_062954968.1 short chain dehydrogenase -
M3X89_RS03935 (M3X89_03935) 773691..774602 + 912 WP_004188550.1 LysR family transcriptional regulator -
M3X89_RS03940 (M3X89_03940) 774603..775751 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
M3X89_RS03945 (M3X89_03945) 775762..777138 - 1377 WP_004217775.1 cystathionine beta-synthase -
M3X89_RS03950 (M3X89_03950) 777783..778076 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
M3X89_RS03955 (M3X89_03955) 778073..778558 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
M3X89_RS03960 (M3X89_03960) 779262..779855 + 594 WP_004188553.1 hypothetical protein -
M3X89_RS03965 (M3X89_03965) 779952..780168 + 217 Protein_780 transposase -
M3X89_RS03970 (M3X89_03970) 780774..781646 + 873 WP_004188557.1 ParA family protein -
M3X89_RS03975 (M3X89_03975) 781646..782029 + 384 WP_004150906.1 hypothetical protein -
M3X89_RS03980 (M3X89_03980) 782022..783389 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 779952..780104 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T245933 WP_004150910.1 NZ_CP097688:778073-778558 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT245933 WP_004150912.1 NZ_CP097688:777783-778076 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References