Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 388084..388730 Replicon chromosome
Accession NZ_CP097688
Organism Klebsiella pneumoniae strain IR12079_1

Toxin (Protein)


Gene name higB Uniprot ID W8UNE1
Locus tag M3X89_RS01870 Protein ID WP_002920560.1
Coordinates 388084..388431 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag M3X89_RS01875 Protein ID WP_002920557.1
Coordinates 388431..388730 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X89_RS01860 (M3X89_01860) 384010..385443 + 1434 WP_002920564.1 glycogen synthase GlgA -
M3X89_RS01865 (M3X89_01865) 385461..387908 + 2448 WP_002920561.1 glycogen phosphorylase -
M3X89_RS01870 (M3X89_01870) 388084..388431 + 348 WP_002920560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M3X89_RS01875 (M3X89_01875) 388431..388730 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
M3X89_RS01880 (M3X89_01880) 388793..390301 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
M3X89_RS01885 (M3X89_01885) 390506..390835 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
M3X89_RS01890 (M3X89_01890) 390886..391716 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
M3X89_RS01895 (M3X89_01895) 391766..392524 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13502.56 Da        Isoelectric Point: 6.2300

>T245932 WP_002920560.1 NZ_CP097688:388084-388431 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRACFAFDPLRKAI
VLCVGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT245932 WP_002920557.1 NZ_CP097688:388431-388730 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CBY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References