Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 315104..315690 Replicon chromosome
Accession NZ_CP097660
Organism Klebsiella pneumoniae strain IR12243_1

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag M3X86_RS01465 Protein ID WP_002920800.1
Coordinates 315322..315690 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0H3GZM4
Locus tag M3X86_RS01460 Protein ID WP_002920802.1
Coordinates 315104..315325 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X86_RS01440 (M3X86_01440) 311261..312187 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
M3X86_RS01445 (M3X86_01445) 312184..313461 + 1278 WP_002920806.1 branched chain amino acid ABC transporter permease LivM -
M3X86_RS01450 (M3X86_01450) 313458..314225 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
M3X86_RS01455 (M3X86_01455) 314227..314940 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
M3X86_RS01460 (M3X86_01460) 315104..315325 + 222 WP_002920802.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M3X86_RS01465 (M3X86_01465) 315322..315690 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
M3X86_RS01470 (M3X86_01470) 315963..317279 + 1317 WP_002920796.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
M3X86_RS01475 (M3X86_01475) 317386..318273 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
M3X86_RS01480 (M3X86_01480) 318270..319115 + 846 WP_002920789.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
M3X86_RS01485 (M3X86_01485) 319117..320187 + 1071 WP_002920787.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 312184..320924 8740


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-49)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T245786 WP_002920800.1 NZ_CP097660:315322-315690 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8181.18 Da        Isoelectric Point: 4.7769

>AT245786 WP_002920802.1 NZ_CP097660:315104-315325 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZM4

References