Detailed information of TA system TA245781

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 41101..41527
• Replicon: plasmid unnamed1
• Accession: NZ_CP097659
• Organism: Klebsiella pneumoniae strain IR12099_1

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: M3X93_RS26985
• Protein ID: WP_001372321.1
• Coordinates: 41402..41527 (+)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	sok
Locus tag	-
Coordinates	41101..41325 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
M3X93_RS26950 (36211)	36211..36666	-	456	Protein_49	hypothetical protein	-
M3X93_RS26955 (36968)	36968..37495	+	528	WP_000290834.1	single-stranded DNA-binding protein	-
M3X93_RS26960 (37553)	37553..37786	+	234	WP_000006003.1	DUF905 family protein	-
M3X93_RS26965 (37847)	37847..39870	+	2024	Protein_52	ParB/RepB/Spo0J family partition protein	-
M3X93_RS26970 (39939)	39939..40373	+	435	WP_000845953.1	conjugation system SOS inhibitor PsiB	-
M3X93_RS26975 (40370)	40370..41089	+	720	WP_001276217.1	plasmid SOS inhibition protein A	-
- (41101)	41101..41325	+	225	NuclAT_0	-	Antitoxin
- (41101)	41101..41325	+	225	NuclAT_0	-	Antitoxin
- (41101)	41101..41325	+	225	NuclAT_0	-	Antitoxin
- (41101)	41101..41325	+	225	NuclAT_0	-	Antitoxin
M3X93_RS26980 (41311)	41311..41460	+	150	Protein_55	plasmid maintenance protein Mok	-
M3X93_RS26985 (41402)	41402..41527	+	126	WP_001372321.1	type I toxin-antitoxin system Hok family toxin	Toxin
M3X93_RS26990 (41846)	41846..42142	-	297	Protein_57	hypothetical protein	-
M3X93_RS26995 (42442)	42442..42738	+	297	WP_001272251.1	hypothetical protein	-
M3X93_RS27000 (42849)	42849..43670	+	822	WP_001234445.1	DUF932 domain-containing protein	-
M3X93_RS27005 (43967)	43967..44614	-	648	WP_015059008.1	transglycosylase SLT domain-containing protein	-
M3X93_RS27010 (44891)	44891..45274	+	384	WP_000124981.1	conjugal transfer relaxosome DNA-binding protein TraM	-
M3X93_RS27015 (45465)	45465..46151	+	687	WP_015059009.1	PAS domain-containing protein	-
M3X93_RS27020 (46245)	46245..46472	+	228	WP_001254386.1	conjugal transfer relaxosome protein TraY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	blaSHV-12 / blaKPC-2	-	1..128678	128678

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4780.69 Da
• Isoelectric Point: 8.5110

>T245781 WP_001372321.1 NZ_CP097659:41402-41527 [Klebsiella pneumoniae]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK

Nucleotide

• Length: 126 bp

Antitoxin

Nucleotide

• Length: 225 bp

>AT245781 NZ_CP097659:41101-41325 [Klebsiella pneumoniae]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTACCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT

Structures

Antitoxin