Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 741293..742068 Replicon chromosome
Accession NZ_CP097658
Organism Klebsiella pneumoniae strain IR12099_1

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag M3X93_RS03700 Protein ID WP_004150910.1
Coordinates 741583..742068 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag M3X93_RS03695 Protein ID WP_004150912.1
Coordinates 741293..741586 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3X93_RS03675 (M3X93_03675) 736501..737103 - 603 WP_062954968.1 short chain dehydrogenase -
M3X93_RS03680 (M3X93_03680) 737201..738112 + 912 WP_004188550.1 LysR family transcriptional regulator -
M3X93_RS03685 (M3X93_03685) 738113..739261 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
M3X93_RS03690 (M3X93_03690) 739272..740648 - 1377 WP_004217775.1 cystathionine beta-synthase -
M3X93_RS03695 (M3X93_03695) 741293..741586 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
M3X93_RS03700 (M3X93_03700) 741583..742068 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
M3X93_RS03705 (M3X93_03705) 742772..743365 + 594 WP_004188553.1 hypothetical protein -
M3X93_RS03710 (M3X93_03710) 743462..743678 + 217 Protein_729 transposase -
M3X93_RS03715 (M3X93_03715) 744284..745156 + 873 WP_004188557.1 ParA family protein -
M3X93_RS03720 (M3X93_03720) 745156..745539 + 384 WP_004150906.1 hypothetical protein -
M3X93_RS03725 (M3X93_03725) 745532..746899 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 743462..743614 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T245766 WP_004150910.1 NZ_CP097658:741583-742068 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT245766 WP_004150912.1 NZ_CP097658:741293-741586 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References