Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 329214..329800 Replicon chromosome
Accession NZ_CP097658
Organism Klebsiella pneumoniae strain IR12099_1

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag M3X93_RS01530 Protein ID WP_002920800.1
Coordinates 329432..329800 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A0H3GZM4
Locus tag M3X93_RS01525 Protein ID WP_002920802.1
Coordinates 329214..329435 (+) Length 74 a.a.

Genomic Context


M3X93_RS01505M3X93_RS01510M3X93_RS01515M3X93_RS01520M3X93_RS01525M3X93_RS01530M3X93_RS01535M3X93_RS01540M3X93_RS01545M3X93_RS01550
Location: 325371..326297 (927 bp)
Type: Others
Protein ID: WP_002920807.1
Location: 326294..327571 (1278 bp)
Type: Others
Protein ID: WP_002920806.1
Location: 327568..328335 (768 bp)
Type: Others
Protein ID: WP_002920803.1
Location: 328337..329050 (714 bp)
Type: Others
Protein ID: WP_004145133.1
Location: 329214..329435 (222 bp)
Type: Antitoxin
Protein ID: WP_002920802.1
Location: 329432..329800 (369 bp)
Type: Toxin
Protein ID: WP_002920800.1
Location: 330072..331388 (1317 bp)
Type: Others
Protein ID: WP_002920796.1
Location: 331495..332382 (888 bp)
Type: Others
Protein ID: WP_002920792.1
Location: 332379..333224 (846 bp)
Type: Others
Protein ID: WP_002920789.1
Location: 333226..334296 (1071 bp)
Type: Others
Protein ID: WP_002920787.1
ToxinAntitoxinOther genes
Loading, please wait
Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
M3X93_RS01505 (M3X93_01505)325371..326297+927WP_002920807.1high-affinity branched-chain amino acid ABC transporter permease LivH-
M3X93_RS01510 (M3X93_01510)326294..327571+1278WP_002920806.1branched chain amino acid ABC transporter permease LivM-
M3X93_RS01515 (M3X93_01515)327568..328335+768WP_002920803.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG-
M3X93_RS01520 (M3X93_01520)328337..329050+714WP_004145133.1high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF-
M3X93_RS01525 (M3X93_01525)329214..329435+222WP_002920802.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
M3X93_RS01530 (M3X93_01530)329432..329800+369WP_002920800.1type II toxin-antitoxin system death-on-curing family toxinToxin
M3X93_RS01535 (M3X93_01535)330072..331388+1317WP_002920796.1sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB-
M3X93_RS01540 (M3X93_01540)331495..332382+888WP_002920792.1sn-glycerol-3-phosphate ABC transporter permease UgpA-
M3X93_RS01545 (M3X93_01545)332379..333224+846WP_002920789.1sn-glycerol-3-phosphate ABC transporter permease UgpE-
M3X93_RS01550 (M3X93_01550)333226..334296+1071WP_002920787.1sn-glycerol-3-phosphate import ATP-binding protein UgpC-

Associated MGEs


Loading, please wait
MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
insideProphage--326294..3350338739


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(13-86)

Antitoxin

(1-49)


Sequences


Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T245764 WP_002920800.1 NZ_CP097658:329432-329800 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp


Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8181.18 Da        Isoelectric Point: 4.7769

>AT245764 WP_002920802.1 NZ_CP097658:329214-329435 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQTARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp


Similar Proteins


Only experimentally validated proteins are listed.

Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
Loading, please wait
Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0H3GUD1


Antitoxin

Loading, please wait
Source
ID
Structure
AlphaFold DBA0A0H3GZM4

References