Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 231066..231668 Replicon chromosome
Accession NC_013889
Organism Thioalkalivibrio sp. K90mix

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag TK90_RS01070 Protein ID WP_012981637.1
Coordinates 231066..231344 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag TK90_RS01075 Protein ID WP_012981638.1
Coordinates 231369..231668 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TK90_RS01045 226625..227497 - 873 WP_012981632.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
TK90_RS01050 227491..228039 - 549 WP_012981633.1 GspH/FimT family pseudopilin -
TK90_RS01055 228243..228665 + 423 WP_012981634.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
TK90_RS01060 228886..229731 + 846 WP_041444120.1 SUMF1/EgtB/PvdO family nonheme iron enzyme -
TK90_RS01065 229968..230960 + 993 WP_012981636.1 IS110 family transposase -
TK90_RS01070 231066..231344 + 279 WP_012981637.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TK90_RS01075 231369..231668 + 300 WP_012981638.1 HigA family addiction module antidote protein Antitoxin
TK90_RS01080 231766..232305 - 540 WP_012981639.1 protein disulfide oxidoreductase -
TK90_RS01085 232302..232733 - 432 WP_041444123.1 hypothetical protein -
TK90_RS01090 232869..233951 + 1083 WP_012981641.1 quinolinate synthase NadA -
TK90_RS01095 233982..234974 - 993 WP_012981642.1 IS110 family transposase -
TK90_RS01100 235255..235461 - 207 WP_012981643.1 hypothetical protein -
TK90_RS01105 235755..236108 + 354 WP_012981644.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 216072..231668 15596


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-83)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10898.28 Da        Isoelectric Point: 8.5553

>T24576 WP_012981637.1 NC_013889:231066-231344 [Thioalkalivibrio sp. K90mix]
MIRSFRCRETRALFETGRSRRWSSVRTIVERKLIQLQAAETLQDLRSPPGNRLEALSGDREGQHSIRINAQWRICFRWTD
EGPEDVEIVDYH

Download         Length: 279 bp

>T24576 NC_013889:231066-231344 [Thioalkalivibrio sp. K90mix]
ATGATCAGAAGCTTTCGGTGTAGGGAAACCCGGGCGCTGTTCGAAACGGGCAGGAGTCGGCGTTGGTCGAGCGTCCGAAC
AATCGTGGAGCGCAAGCTGATTCAGCTTCAAGCGGCGGAGACACTGCAGGATTTGCGTTCTCCGCCGGGGAACCGGCTGG
AGGCCCTGTCTGGCGACCGCGAAGGGCAGCACAGCATCCGAATCAACGCCCAGTGGCGCATCTGTTTCCGGTGGACGGAC
GAAGGTCCCGAGGATGTGGAGATCGTCGATTACCACTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 11320.99 Da        Isoelectric Point: 8.6802

>AT24576 WP_012981638.1 NC_013889:231369-231668 [Thioalkalivibrio sp. K90mix]
MSTSGMRPIHPGEVLREEFLAPLGLSVNALAGALHVPTTRMNDIVRERRGISADTAMRLARYFGTSERFWLNLQLEYELR
QAQLELSERVRREIEPRAA

Download         Length: 300 bp

>AT24576 NC_013889:231369-231668 [Thioalkalivibrio sp. K90mix]
ATGAGCACAAGCGGTATGCGACCCATCCATCCAGGTGAGGTCCTGCGCGAGGAGTTTCTTGCCCCGTTGGGTCTCAGTGT
GAACGCGCTTGCTGGGGCATTGCATGTTCCGACGACGCGCATGAACGACATTGTGCGCGAGCGTCGTGGCATTTCGGCTG
ACACGGCCATGAGGTTGGCGCGTTATTTCGGCACTTCCGAGCGTTTCTGGCTGAACCTCCAGCTCGAGTATGAACTGAGG
CAGGCGCAACTCGAACTTTCGGAACGCGTGCGTCGTGAAATTGAGCCGCGGGCGGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References