Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 2854119..2854894 Replicon chromosome
Accession NZ_CP097654
Organism Klebsiella pneumoniae strain IR1272_1

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag M3T50_RS13890 Protein ID WP_004150910.1
Coordinates 2854409..2854894 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag M3T50_RS13885 Protein ID WP_004150912.1
Coordinates 2854119..2854412 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3T50_RS13865 (M3T50_13865) 2849327..2849929 - 603 WP_062954968.1 short chain dehydrogenase -
M3T50_RS13870 (M3T50_13870) 2850027..2850938 + 912 WP_004188550.1 LysR family transcriptional regulator -
M3T50_RS13875 (M3T50_13875) 2850939..2852087 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
M3T50_RS13880 (M3T50_13880) 2852098..2853474 - 1377 WP_004217775.1 cystathionine beta-synthase -
M3T50_RS13885 (M3T50_13885) 2854119..2854412 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
M3T50_RS13890 (M3T50_13890) 2854409..2854894 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
M3T50_RS13895 (M3T50_13895) 2855598..2856191 + 594 WP_004188553.1 hypothetical protein -
M3T50_RS13900 (M3T50_13900) 2856288..2856504 + 217 Protein_2700 transposase -
M3T50_RS13905 (M3T50_13905) 2857110..2857982 + 873 WP_004188557.1 ParA family protein -
M3T50_RS13910 (M3T50_13910) 2857982..2858365 + 384 WP_004150906.1 hypothetical protein -
M3T50_RS13915 (M3T50_13915) 2858358..2859725 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2856288..2856440 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T245750 WP_004150910.1 NZ_CP097654:2854409-2854894 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT245750 WP_004150912.1 NZ_CP097654:2854119-2854412 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References