Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 2464386..2465032 Replicon chromosome
Accession NZ_CP097654
Organism Klebsiella pneumoniae strain IR1272_1

Toxin (Protein)


Gene name higB Uniprot ID W8UNE1
Locus tag M3T50_RS11815 Protein ID WP_002920560.1
Coordinates 2464386..2464733 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag M3T50_RS11820 Protein ID WP_002920557.1
Coordinates 2464733..2465032 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M3T50_RS11805 (M3T50_11805) 2460312..2461745 + 1434 WP_002920564.1 glycogen synthase GlgA -
M3T50_RS11810 (M3T50_11810) 2461763..2464210 + 2448 WP_002920561.1 glycogen phosphorylase -
M3T50_RS11815 (M3T50_11815) 2464386..2464733 + 348 WP_002920560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M3T50_RS11820 (M3T50_11820) 2464733..2465032 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
M3T50_RS11825 (M3T50_11825) 2465095..2466603 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
M3T50_RS11830 (M3T50_11830) 2466808..2467137 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
M3T50_RS11835 (M3T50_11835) 2467188..2468018 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
M3T50_RS11840 (M3T50_11840) 2468068..2468826 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13502.56 Da        Isoelectric Point: 6.2300

>T245749 WP_002920560.1 NZ_CP097654:2464386-2464733 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRACFAFDPLRKAI
VLCVGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT245749 WP_002920557.1 NZ_CP097654:2464733-2465032 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CBY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References