Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 733763..734538 Replicon chromosome
Accession NZ_CP097651
Organism Klebsiella pneumoniae strain NK01067

Toxin (Protein)


Gene name TacT2 Uniprot ID B6ZBI6
Locus tag M8Y62_RS03625 Protein ID WP_004889762.1
Coordinates 734053..734538 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag M8Y62_RS03620 Protein ID WP_004150912.1
Coordinates 733763..734056 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y62_RS03600 (728972) 728972..729574 - 603 WP_002916735.1 short chain dehydrogenase -
M8Y62_RS03605 (729672) 729672..730583 + 912 WP_014906929.1 LysR family transcriptional regulator -
M8Y62_RS03610 (730584) 730584..731732 - 1149 WP_014906930.1 PLP-dependent aspartate aminotransferase family protein -
M8Y62_RS03615 (731743) 731743..733119 - 1377 WP_014906931.1 pyridoxal-phosphate dependent enzyme -
M8Y62_RS03620 (733763) 733763..734056 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
M8Y62_RS03625 (734053) 734053..734538 + 486 WP_004889762.1 GNAT family N-acetyltransferase Toxin
M8Y62_RS03630 (735242) 735242..735835 + 594 WP_004188553.1 hypothetical protein -
M8Y62_RS03635 (735932) 735932..736148 + 217 Protein_715 transposase -
M8Y62_RS03645 (736826) 736826..737539 - 714 WP_002916694.1 DUF554 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 735932..736084 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17585.56 Da        Isoelectric Point: 8.5144

>T245729 WP_004889762.1 NZ_CP097651:734053-734538 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDSMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT245729 WP_004150912.1 NZ_CP097651:733763-734056 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A447W563

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References