Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 3754093..3754690 Replicon chromosome
Accession NZ_CP097646
Organism Klebsiella quasipneumoniae strain NE1

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M8232_RS18210 Protein ID WP_108450630.1
Coordinates 3754373..3754690 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M8232_RS18205 Protein ID WP_108450629.1
Coordinates 3754093..3754380 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8232_RS18175 (3750180) 3750180..3750428 + 249 WP_002893037.1 DUF1158 domain-containing protein -
M8232_RS18180 (3750446) 3750446..3750787 - 342 WP_004202492.1 RamA family antibiotic efflux transcriptional regulator -
M8232_RS18185 (3750818) 3750818..3751933 - 1116 WP_025999133.1 MBL fold metallo-hydrolase -
M8232_RS18190 (3752113) 3752113..3752694 + 582 WP_017899014.1 TetR/AcrR family transcriptional regulator -
M8232_RS18195 (3752694) 3752694..3753062 + 369 WP_004202487.1 MmcQ/YjbR family DNA-binding protein -
M8232_RS18200 (3753182) 3753182..3753835 + 654 WP_108450628.1 oxygen-insensitive NAD(P)H nitroreductase -
M8232_RS18205 (3754093) 3754093..3754380 - 288 WP_108450629.1 helix-turn-helix transcriptional regulator Antitoxin
M8232_RS18210 (3754373) 3754373..3754690 - 318 WP_108450630.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8232_RS18215 (3754875) 3754875..3755918 - 1044 WP_060656299.1 hypothetical protein -
M8232_RS18220 (3756456) 3756456..3757322 - 867 WP_158239951.1 helix-turn-helix transcriptional regulator -
M8232_RS18225 (3757431) 3757431..3758858 + 1428 WP_023319904.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-100)

Antitoxin

Cro/C1-type helix-turn-helix domain

(38-88)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12197.57 Da        Isoelectric Point: 11.2767

>T245716 WP_108450630.1 NZ_CP097646:c3754690-3754373 [Klebsiella quasipneumoniae]
MFRMVVHVDVKKELQALPAIVQAKMIRQLDKLRQNPTALREPDSKPLGQGLFEIRALGSVQGRGIYVFQQNKTLFLLRVF
VKKTQKIPLSEIRLALKRLEEMRNE

Download         Length: 318 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10840.56 Da        Isoelectric Point: 10.4518

>AT245716 WP_108450629.1 NZ_CP097646:c3754380-3754093 [Klebsiella quasipneumoniae]
MSKKIIDWDTLKTELLSQPEVQAAFDAQERKHRLRTMLAQWREQAGLTRAQVAQRMGVSAPTVSRMEANITRTSLDTLTR
YALACGIKHPQVLLY

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References