Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/Tad-HTH_37
Location 1533318..1533891 Replicon chromosome
Accession NZ_CP097635
Organism Aquincola tertiaricarbonis strain RN12

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MW290_RS07085 Protein ID WP_250196549.1
Coordinates 1533318..1533617 (+) Length 100 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MW290_RS07090 Protein ID WP_250196550.1
Coordinates 1533604..1533891 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MW290_RS07060 (MW290_07060) 1528679..1529419 - 741 WP_250196544.1 HisA/HisF-related TIM barrel protein -
MW290_RS07065 (MW290_07065) 1529432..1530367 + 936 WP_250196545.1 ATP-grasp domain-containing protein -
MW290_RS07070 (MW290_07070) 1530360..1531448 + 1089 WP_250196546.1 hydantoinase/oxoprolinase family protein -
MW290_RS07075 (MW290_07075) 1531449..1532048 + 600 WP_250196547.1 aspartate kinase -
MW290_RS07080 (MW290_07080) 1532230..1533210 + 981 WP_250196548.1 tripartite tricarboxylate transporter substrate binding protein -
MW290_RS07085 (MW290_07085) 1533318..1533617 + 300 WP_250196549.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MW290_RS07090 (MW290_07090) 1533604..1533891 + 288 WP_250196550.1 helix-turn-helix transcriptional regulator Antitoxin
MW290_RS07095 (MW290_07095) 1533907..1535370 - 1464 WP_250196551.1 glucose-6-phosphate dehydrogenase -
MW290_RS07100 (MW290_07100) 1535584..1537686 + 2103 WP_250196552.1 elongation factor G -
MW290_RS07105 (MW290_07105) 1537766..1538485 + 720 WP_250196553.1 protein N-lysine methyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(3-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(35-91)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11196.27 Da        Isoelectric Point: 11.0232

>T245702 WP_250196549.1 NZ_CP097635:1533318-1533617 [Aquincola tertiaricarbonis]
VVEEILALPDTLAARYVVLTRRIMAVGPNLGAPHTDAFGEGLFELRLKGQEGIARVFFCALVGRRVMMLHSFIKKTQRTP
QREIEVARKRMKEVKHANP

Download         Length: 300 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.16 Da        Isoelectric Point: 10.4671

>AT245702 WP_250196550.1 NZ_CP097635:1533604-1533891 [Aquincola tertiaricarbonis]
MRTHDDVVAKLMKRPGVRKEVERIEREEGALLDLLLKAREEAGLSQAQVAERMGTHAPAVARLERALATGKHSPSLATLR
KYAQACGKTLSLHLT

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References