Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1846672..1847432 Replicon chromosome
Accession NZ_CP097622
Organism Pasteurella multocida strain P2723

Toxin (Protein)


Gene name higB Uniprot ID A0A2J9QLH7
Locus tag M8856_RS08555 Protein ID WP_005725755.1
Coordinates 1846672..1846998 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M8856_RS08560 Protein ID WP_005757699.1
Coordinates 1847106..1847432 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8856_RS08530 (M8856_08530) 1841973..1842659 + 687 WP_163884196.1 hypothetical protein -
M8856_RS08535 (M8856_08535) 1842713..1844242 - 1530 WP_005757692.1 YifB family Mg chelatase-like AAA ATPase -
M8856_RS08540 (M8856_08540) 1844350..1844967 - 618 WP_005718080.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
M8856_RS08545 (M8856_08545) 1845078..1845947 + 870 WP_064973201.1 VirK/YbjX family protein -
M8856_RS08550 (M8856_08550) 1846022..1846498 - 477 WP_005755093.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
M8856_RS08555 (M8856_08555) 1846672..1846998 + 327 WP_005725755.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8856_RS08560 (M8856_08560) 1847106..1847432 + 327 WP_005757699.1 HigA family addiction module antitoxin Antitoxin
M8856_RS08565 (M8856_08565) 1847486..1849006 - 1521 WP_250032409.1 surface lipoprotein assembly modifier -
M8856_RS08570 (M8856_08570) 1849065..1849667 - 603 WP_010907202.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
M8856_RS08575 (M8856_08575) 1849718..1850725 - 1008 WP_250032411.1 protein PlpE -
M8856_RS08580 (M8856_08580) 1850963..1851985 - 1023 WP_250032413.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-102)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12892.73 Da        Isoelectric Point: 9.6705

>T245673 WP_005725755.1 NZ_CP097622:1846672-1846998 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSPPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT245673 WP_005757699.1 NZ_CP097622:1847106-1847432 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QLH7

Antitoxin

Source ID Structure

References