Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1815269..1816036 Replicon chromosome
Accession NZ_CP097620
Organism Pasteurella multocida strain P2192

Toxin (Protein)


Gene name higB Uniprot ID A0A2J9QLH7
Locus tag M8855_RS08375 Protein ID WP_005725755.1
Coordinates 1815269..1815595 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M8855_RS08380 Protein ID WP_005757699.1
Coordinates 1815710..1816036 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8855_RS08350 (M8855_08350) 1810587..1811273 + 687 WP_169323088.1 hypothetical protein -
M8855_RS08355 (M8855_08355) 1811327..1812856 - 1530 WP_249984199.1 YifB family Mg chelatase-like AAA ATPase -
M8855_RS08360 (M8855_08360) 1812964..1813581 - 618 WP_005718080.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
M8855_RS08365 (M8855_08365) 1813692..1814561 + 870 WP_014668443.1 VirK/YbjX family protein -
M8855_RS08370 (M8855_08370) 1814635..1815111 - 477 WP_005757697.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
M8855_RS08375 (M8855_08375) 1815269..1815595 + 327 WP_005725755.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8855_RS08380 (M8855_08380) 1815710..1816036 + 327 WP_005757699.1 HigA family addiction module antitoxin Antitoxin
M8855_RS08385 (M8855_08385) 1816090..1817610 - 1521 WP_249984198.1 surface lipoprotein assembly modifier -
M8855_RS08390 (M8855_08390) 1817669..1818271 - 603 WP_010907202.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
M8855_RS08395 (M8855_08395) 1818322..1819329 - 1008 WP_250190466.1 protein PlpE -
M8855_RS08400 (M8855_08400) 1819566..1820597 - 1032 WP_130525555.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-102)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12892.73 Da        Isoelectric Point: 9.6705

>T245671 WP_005725755.1 NZ_CP097620:1815269-1815595 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSPPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT245671 WP_005757699.1 NZ_CP097620:1815710-1816036 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QLH7

Antitoxin

Source ID Structure

References