Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1882197..1882929 Replicon chromosome
Accession NZ_CP097618
Organism Pasteurella multocida strain P2095

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M8854_RS08755 Protein ID WP_064965342.1
Coordinates 1882197..1882523 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M8854_RS08760 Protein ID WP_005757699.1
Coordinates 1882603..1882929 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8854_RS08730 (M8854_08730) 1877513..1878199 + 687 WP_064965338.1 hypothetical protein -
M8854_RS08735 (M8854_08735) 1878253..1879782 - 1530 WP_064965339.1 YifB family Mg chelatase-like AAA ATPase -
M8854_RS08740 (M8854_08740) 1879891..1880508 - 618 WP_005724253.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
M8854_RS08745 (M8854_08745) 1880619..1881488 + 870 WP_064965340.1 VirK/YbjX family protein -
M8854_RS08750 (M8854_08750) 1881563..1882039 - 477 WP_064965341.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
M8854_RS08755 (M8854_08755) 1882197..1882523 + 327 WP_064965342.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8854_RS08760 (M8854_08760) 1882603..1882929 + 327 WP_005757699.1 HigA family addiction module antitoxin Antitoxin
M8854_RS08765 (M8854_08765) 1882983..1884503 - 1521 WP_064965343.1 surface lipoprotein assembly modifier -
M8854_RS08770 (M8854_08770) 1884562..1885164 - 603 WP_005755098.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
M8854_RS08775 (M8854_08775) 1885215..1886222 - 1008 WP_064965344.1 protein PlpE -
M8854_RS08780 (M8854_08780) 1886459..1887508 - 1050 WP_064965345.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-102)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12846.66 Da        Isoelectric Point: 9.6705

>T245669 WP_064965342.1 NZ_CP097618:1882197-1882523 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSPPGNKLEKLEPKTTGLYSIRVNV
KYRLIFKYKESNSPKITELRLDKHQYRL

Download         Length: 327 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT245669 WP_005757699.1 NZ_CP097618:1882603-1882929 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References