Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1868517..1869228 Replicon chromosome
Accession NZ_CP097616
Organism Pasteurella multocida strain P1702

Toxin (Protein)


Gene name higB Uniprot ID A0A2J9QLH7
Locus tag M8853_RS08600 Protein ID WP_005725755.1
Coordinates 1868517..1868843 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M8853_RS08605 Protein ID WP_005757699.1
Coordinates 1868902..1869228 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8853_RS08575 (M8853_08575) 1863835..1864521 + 687 WP_059245891.1 hypothetical protein -
M8853_RS08580 (M8853_08580) 1864575..1866104 - 1530 WP_064973202.1 YifB family Mg chelatase-like AAA ATPase -
M8853_RS08585 (M8853_08585) 1866212..1866829 - 618 WP_005718080.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
M8853_RS08590 (M8853_08590) 1866940..1867809 + 870 WP_064973201.1 VirK/YbjX family protein -
M8853_RS08595 (M8853_08595) 1867883..1868359 - 477 WP_005755093.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
M8853_RS08600 (M8853_08600) 1868517..1868843 + 327 WP_005725755.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8853_RS08605 (M8853_08605) 1868902..1869228 + 327 WP_005757699.1 HigA family addiction module antitoxin Antitoxin
M8853_RS08610 (M8853_08610) 1869283..1870803 - 1521 WP_064973200.1 surface lipoprotein assembly modifier -
M8853_RS08615 (M8853_08615) 1870862..1871464 - 603 WP_005757703.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
M8853_RS08620 (M8853_08620) 1871515..1872522 - 1008 WP_064973199.1 protein PlpE -
M8853_RS08625 (M8853_08625) 1872760..1873827 - 1068 WP_064973198.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-102)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12892.73 Da        Isoelectric Point: 9.6705

>T245666 WP_005725755.1 NZ_CP097616:1868517-1868843 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSPPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT245666 WP_005757699.1 NZ_CP097616:1868902-1869228 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QLH7

Antitoxin

Source ID Structure

References