Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1804220..1805008 Replicon chromosome
Accession NZ_CP097614
Organism Pasteurella multocida strain P1581

Toxin (Protein)


Gene name higB Uniprot ID A0A2J9QLH7
Locus tag M8852_RS08350 Protein ID WP_005725755.1
Coordinates 1804220..1804546 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M8852_RS08355 Protein ID WP_005757699.1
Coordinates 1804682..1805008 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8852_RS08325 (M8852_08325) 1799538..1800224 + 687 WP_104227953.1 hypothetical protein -
M8852_RS08330 (M8852_08330) 1800278..1801807 - 1530 WP_115098073.1 YifB family Mg chelatase-like AAA ATPase -
M8852_RS08335 (M8852_08335) 1801915..1802532 - 618 WP_005724253.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
M8852_RS08340 (M8852_08340) 1802643..1803512 + 870 WP_005724254.1 VirK/YbjX family protein -
M8852_RS08345 (M8852_08345) 1803586..1804062 - 477 WP_042742721.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
M8852_RS08350 (M8852_08350) 1804220..1804546 + 327 WP_005725755.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8852_RS08355 (M8852_08355) 1804682..1805008 + 327 WP_005757699.1 HigA family addiction module antitoxin Antitoxin
M8852_RS08360 (M8852_08360) 1805063..1806583 - 1521 WP_115098072.1 surface lipoprotein assembly modifier -
M8852_RS08365 (M8852_08365) 1806642..1807244 - 603 WP_005724259.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
M8852_RS08370 (M8852_08370) 1807295..1808311 - 1017 WP_172459827.1 protein PlpE -
M8852_RS08375 (M8852_08375) 1808558..1809589 - 1032 WP_115098071.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-102)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12892.73 Da        Isoelectric Point: 9.6705

>T245664 WP_005725755.1 NZ_CP097614:1804220-1804546 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSPPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT245664 WP_005757699.1 NZ_CP097614:1804682-1805008 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QLH7

Antitoxin

Source ID Structure

References