Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1992744..1993483 Replicon chromosome
Accession NZ_CP097612
Organism Pasteurella multocida strain 33011

Toxin (Protein)


Gene name higB Uniprot ID A0A2J9QLH7
Locus tag M8851_RS09585 Protein ID WP_005725755.1
Coordinates 1992744..1993070 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M8851_RS09590 Protein ID WP_005757699.1
Coordinates 1993157..1993483 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8851_RS09560 (M8851_09560) 1988062..1988748 + 687 WP_005755085.1 hypothetical protein -
M8851_RS09565 (M8851_09565) 1988802..1990330 - 1529 Protein_1849 YifB family Mg chelatase-like AAA ATPase -
M8851_RS09570 (M8851_09570) 1990438..1991055 - 618 WP_005755089.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
M8851_RS09575 (M8851_09575) 1991166..1992035 + 870 WP_005755091.1 VirK/YbjX family protein -
M8851_RS09580 (M8851_09580) 1992110..1992586 - 477 WP_005755093.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
M8851_RS09585 (M8851_09585) 1992744..1993070 + 327 WP_005725755.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8851_RS09590 (M8851_09590) 1993157..1993483 + 327 WP_005757699.1 HigA family addiction module antitoxin Antitoxin
M8851_RS09595 (M8851_09595) 1993537..1995057 - 1521 WP_005755096.1 surface lipoprotein assembly modifier -
M8851_RS09600 (M8851_09600) 1995116..1995718 - 603 WP_005755098.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
M8851_RS09605 (M8851_09605) 1995769..1996782 - 1014 WP_250192343.1 protein PlpE -
M8851_RS09610 (M8851_09610) 1997020..1998060 - 1041 WP_250190571.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-102)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12892.73 Da        Isoelectric Point: 9.6705

>T245663 WP_005725755.1 NZ_CP097612:1992744-1993070 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSPPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT245663 WP_005757699.1 NZ_CP097612:1993157-1993483 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QLH7

Antitoxin

Source ID Structure

References