Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1977776..1978522 Replicon chromosome
Accession NZ_CP097610
Organism Pasteurella multocida strain 32985

Toxin (Protein)


Gene name higB Uniprot ID A0A2J9QLH7
Locus tag M8850_RS09485 Protein ID WP_005725755.1
Coordinates 1977776..1978102 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M8850_RS09490 Protein ID WP_005757699.1
Coordinates 1978196..1978522 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8850_RS09460 (M8850_09460) 1973094..1973780 + 687 WP_005755085.1 hypothetical protein -
M8850_RS09465 (M8850_09465) 1973834..1975362 - 1529 Protein_1831 YifB family Mg chelatase-like AAA ATPase -
M8850_RS09470 (M8850_09470) 1975470..1976087 - 618 WP_005755089.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
M8850_RS09475 (M8850_09475) 1976198..1977067 + 870 WP_005755091.1 VirK/YbjX family protein -
M8850_RS09480 (M8850_09480) 1977142..1977618 - 477 WP_005755093.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
M8850_RS09485 (M8850_09485) 1977776..1978102 + 327 WP_005725755.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8850_RS09490 (M8850_09490) 1978196..1978522 + 327 WP_005757699.1 HigA family addiction module antitoxin Antitoxin
M8850_RS09495 (M8850_09495) 1978576..1980096 - 1521 WP_005755096.1 surface lipoprotein assembly modifier -
M8850_RS09500 (M8850_09500) 1980155..1980757 - 603 WP_005755098.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
M8850_RS09505 (M8850_09505) 1980808..1981821 - 1014 WP_250190570.1 protein PlpE -
M8850_RS09510 (M8850_09510) 1982059..1983099 - 1041 WP_250190571.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-102)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12892.73 Da        Isoelectric Point: 9.6705

>T245662 WP_005725755.1 NZ_CP097610:1977776-1978102 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSPPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT245662 WP_005757699.1 NZ_CP097610:1978196-1978522 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QLH7

Antitoxin

Source ID Structure

References