Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1838813..1839573 Replicon chromosome
Accession NZ_CP097604
Organism Pasteurella multocida strain 10159

Toxin (Protein)


Gene name higB Uniprot ID A0A2J9QLH7
Locus tag M8331_RS08610 Protein ID WP_005725755.1
Coordinates 1838813..1839139 (+) Length 109 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M8331_RS08615 Protein ID WP_005757699.1
Coordinates 1839247..1839573 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8331_RS08585 (M8331_08585) 1834130..1834816 + 687 WP_061406323.1 hypothetical protein -
M8331_RS08590 (M8331_08590) 1834870..1836399 - 1530 WP_061406324.1 YifB family Mg chelatase-like AAA ATPase -
M8331_RS08595 (M8331_08595) 1836508..1837125 - 618 WP_005724253.1 ribosome biogenesis GTP-binding protein YihA/YsxC -
M8331_RS08600 (M8331_08600) 1837236..1838105 + 870 WP_061406325.1 VirK/YbjX family protein -
M8331_RS08605 (M8331_08605) 1838179..1838655 - 477 WP_042742721.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
M8331_RS08610 (M8331_08610) 1838813..1839139 + 327 WP_005725755.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8331_RS08615 (M8331_08615) 1839247..1839573 + 327 WP_005757699.1 HigA family addiction module antitoxin Antitoxin
M8331_RS08620 (M8331_08620) 1839628..1841148 - 1521 WP_083003944.1 surface lipoprotein assembly modifier -
M8331_RS08625 (M8331_08625) 1841207..1841797 - 591 WP_102955899.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
M8331_RS08630 (M8331_08630) 1841860..1842870 - 1011 WP_083003938.1 protein PlpE -
M8331_RS08635 (M8331_08635) 1843106..1844122 - 1017 WP_083003936.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(12-104)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-102)


Sequences

Toxin        


Download         Length: 109 a.a.        Molecular weight: 12892.73 Da        Isoelectric Point: 9.6705

>T245654 WP_005725755.1 NZ_CP097604:1838813-1839139 [Pasteurella multocida]
MDRVRFNLTEDSFQDKYLYEYFLYGSKHKNIPSDIENTLAHKLDMLDSANTLSDLRSPPGNKLEKLEPKTSGLYSIRVNV
KYRLIFKYKESNFPKITELRLDKHQYRL

Download         Length: 327 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12377.41 Da        Isoelectric Point: 7.2034

>AT245654 WP_005757699.1 NZ_CP097604:1839247-1839573 [Pasteurella multocida]
MSRVQRKPSTVGDILLDEYLVPLNLKIADLATMLDVHRNTASALVNNNTKLSLEMALKLAKLFNTSPEFWLNLQMKLDLW
EIENNARFQESLKKISSIDQHNLLEKIA

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J9QLH7

Antitoxin

Source ID Structure

References