Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1847069..1847674 Replicon chromosome
Accession NZ_CP097576
Organism Microcystis aeruginosa str. Chao 1910

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag M8120_RS09275 Protein ID WP_190358824.1
Coordinates 1847393..1847674 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M8120_RS09270 Protein ID WP_190358823.1
Coordinates 1847069..1847383 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8120_RS09255 (M8120_09160) 1842711..1843802 + 1092 WP_265795848.1 ISAs1 family transposase -
M8120_RS09260 (M8120_09165) 1844253..1846409 - 2157 Protein_1835 tetratricopeptide repeat protein -
M8120_RS09265 (M8120_09170) 1846559..1846900 - 342 WP_242030171.1 hypothetical protein -
M8120_RS09270 (M8120_09175) 1847069..1847383 - 315 WP_190358823.1 HigA family addiction module antitoxin Antitoxin
M8120_RS09275 (M8120_09180) 1847393..1847674 - 282 WP_190358824.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8120_RS09280 (M8120_09185) 1847980..1848132 - 153 WP_190358825.1 hypothetical protein -
M8120_RS09285 (M8120_09190) 1848315..1848575 + 261 WP_002740817.1 hypothetical protein -
M8120_RS09290 (M8120_09195) 1848562..1848984 + 423 WP_190358826.1 type II toxin-antitoxin system VapC family toxin -
M8120_RS09295 (M8120_09200) 1849096..1849377 - 282 WP_002736843.1 hemolysin XhlA family protein -
M8120_RS09300 (M8120_09205) 1849558..1852077 - 2520 WP_190358827.1 glycogen/starch/alpha-glucan phosphorylase -
M8120_RS09305 (M8120_09210) 1852276..1852569 - 294 WP_190358828.1 RNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-69)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 11085.68 Da        Isoelectric Point: 9.7184

>T245622 WP_190358824.1 NZ_CP097576:c1847674-1847393 [Microcystis aeruginosa str. Chao 1910]
VIQNFKDKEAQKVFERKHSRKLPLDIQQVALRKLRMLNRAETLQDLRVPPANRLERLVGDREGQYSIRVNDQWRICFVWQ
NGDALDGEIVDYH

Download         Length: 282 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11802.77 Da        Isoelectric Point: 4.2285

>AT245622 WP_190358823.1 NZ_CP097576:c1847383-1847069 [Microcystis aeruginosa str. Chao 1910]
MNEDKLMPIHPGEVLLEEFIKPMNLSQNQIALALGVPEQCINEIVHGKRCITADIALRLARYFDMSPRFWLGLQMDYDLD
VVEDEIGDQLAKEVAVMTVICAEK

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References