Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2342690..2343285 Replicon chromosome
Accession NZ_CP097575
Organism Pseudomonas aeruginosa strain UNC_PaerCF25

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag M9A05_RS10750 Protein ID WP_003113526.1
Coordinates 2343007..2343285 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M9A05_RS10745 Protein ID WP_003099268.1
Coordinates 2342690..2342995 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M9A05_RS10710 (M9A05_10710) 2337830..2338678 + 849 WP_003099284.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
M9A05_RS10720 (M9A05_10720) 2338845..2339786 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
M9A05_RS10725 (M9A05_10725) 2339903..2340517 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
M9A05_RS10730 (M9A05_10730) 2340559..2341143 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
M9A05_RS10735 (M9A05_10735) 2341184..2342284 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
M9A05_RS10745 (M9A05_10745) 2342690..2342995 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
M9A05_RS10750 (M9A05_10750) 2343007..2343285 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M9A05_RS10755 (M9A05_10755) 2343338..2343466 - 129 Protein_2130 integrase -
M9A05_RS10760 (M9A05_10760) 2343614..2345842 + 2229 WP_250177723.1 TonB-dependent receptor -
M9A05_RS10765 (M9A05_10765) 2345912..2346559 - 648 WP_003095021.1 carbonate dehydratase -
M9A05_RS10770 (M9A05_10770) 2346621..2347859 - 1239 WP_003111578.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T245614 WP_003113526.1 NZ_CP097575:c2343285-2343007 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT245614 WP_003099268.1 NZ_CP097575:c2342995-2342690 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References