Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1220685..1221334 Replicon chromosome
Accession NZ_CP097572
Organism Enterobacter kobei strain C210239

Toxin (Protein)


Gene name higB Uniprot ID A0A2J0PLQ3
Locus tag M8978_RS05695 Protein ID WP_014882864.1
Coordinates 1220972..1221334 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2W0GCS7
Locus tag M8978_RS05690 Protein ID WP_014882863.1
Coordinates 1220685..1220984 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8978_RS05680 (M8978_05680) 1217110..1219083 + 1974 WP_023336850.1 PhoX family phosphatase -
M8978_RS05685 (M8978_05685) 1219186..1220574 + 1389 WP_014882862.1 phenylalanine transporter -
M8978_RS05690 (M8978_05690) 1220685..1220984 - 300 WP_014882863.1 helix-turn-helix transcriptional regulator Antitoxin
M8978_RS05695 (M8978_05695) 1220972..1221334 - 363 WP_014882864.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8978_RS05700 (M8978_05700) 1221540..1222775 + 1236 WP_023332295.1 MFS transporter -
M8978_RS05705 (M8978_05705) 1222791..1223816 + 1026 WP_059372448.1 sugar phosphate isomerase/epimerase family protein -
M8978_RS05710 (M8978_05710) 1223809..1224951 + 1143 WP_059372452.1 Gfo/Idh/MocA family oxidoreductase -
M8978_RS05715 (M8978_05715) 1225027..1225998 + 972 WP_047626963.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-80)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13952.92 Da        Isoelectric Point: 6.7114

>T245604 WP_014882864.1 NZ_CP097572:c1221334-1220972 [Enterobacter kobei]
MWNVETTDRFDQWYFEQTTALKEDVLAMMHILAEFGPTLGRPYVDTVKASAYANMKELRIQHAGNPIRAFFAFDPDRKAI
VLCAGNKTGCNQKRFYNEMITLADVEYSRHLADKEAIWQR

Download         Length: 363 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10860.61 Da        Isoelectric Point: 9.8627

>AT245604 WP_014882863.1 NZ_CP097572:c1220984-1220685 [Enterobacter kobei]
MATLKELMAQQSAESQERIAAKVDVIRRIVALNQLREELNISQTELAAAMGVKQPTVAKIEQPGNDPRLSTLKRYVSALG
GEMSIDVTLPNGKRIAFQI

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PLQ3

Antitoxin

Source ID Structure
AlphaFold DB A0A2W0GCS7

References