245599

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2516299..2516822 Replicon chromosome
Accession NZ_CP097571
Organism Staphylococcus aureus strain V40

Toxin (Protein)


Gene name yoeB Uniprot ID X5DYX7
Locus tag M8789_RS12540 Protein ID WP_000074048.1
Coordinates 2516299..2516565 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S6D1W5
Locus tag M8789_RS12545 Protein ID WP_000587617.1
Coordinates 2516565..2516822 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8789_RS12520 (2511518) 2511518..2512705 - 1188 WP_000026189.1 MFS transporter -
M8789_RS12525 (2513100) 2513100..2513876 - 777 WP_000072160.1 iron export ABC transporter permease subunit FetB -
M8789_RS12530 (2513869) 2513869..2514531 - 663 WP_000923508.1 ATP-binding cassette domain-containing protein -
M8789_RS12535 (2514876) 2514876..2515943 - 1068 WP_001076685.1 M42 family metallopeptidase -
M8789_RS12540 (2516299) 2516299..2516565 - 267 WP_000074048.1 Txe/YoeB family addiction module toxin Toxin
M8789_RS12545 (2516565) 2516565..2516822 - 258 WP_000587617.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M8789_RS12550 (2517182) 2517182..2517637 + 456 WP_000732082.1 DUF1307 domain-containing protein -
M8789_RS12555 (2517805) 2517805..2519382 - 1578 WP_000143506.1 FMN-binding glutamate synthase family protein -
M8789_RS12560 (2519576) 2519576..2520325 + 750 WP_000072456.1 CPBP family lipoprotein N-acylation protein LnsB -
M8789_RS12565 (2520549) 2520549..2521742 - 1194 WP_000675402.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(25-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10648.23 Da        Isoelectric Point: 10.1384

>T245599 WP_000074048.1 NZ_CP097571:c2516565-2516299 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLKKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9747.71 Da        Isoelectric Point: 4.1353

>AT245599 WP_000587617.1 NZ_CP097571:c2516822-2516565 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDSSGTTNIDDI
DWDNL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7V6W
PDB 7V5Y
PDB 7V5Z

Antitoxin

Source ID Structure
AlphaFold DB A0A2S6D1W5

References