245597

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2459618..2460135 Replicon chromosome
Accession NZ_CP097571
Organism Staphylococcus aureus strain V40

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag M8789_RS12265 Protein ID WP_000113260.1
Coordinates 2459618..2459884 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID T1YB60
Locus tag M8789_RS12270 Protein ID WP_000584499.1
Coordinates 2459884..2460135 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8789_RS12235 (2454714) 2454714..2455250 - 537 WP_000185901.1 GNAT family N-acetyltransferase -
M8789_RS12240 (2455828) 2455828..2456652 - 825 WP_000594633.1 formate/nitrite transporter family protein -
M8789_RS12245 (2456855) 2456855..2457037 - 183 WP_000079140.1 hypothetical protein -
M8789_RS12250 (2457124) 2457124..2457591 - 468 WP_000153340.1 SRPBCC domain-containing protein -
M8789_RS12255 (2457777) 2457777..2459324 - 1548 WP_000727756.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
M8789_RS12260 (2459503) 2459503..2459583 - 81 WP_225539491.1 hypothetical protein -
M8789_RS12265 (2459618) 2459618..2459884 - 267 WP_000113260.1 Txe/YoeB family addiction module toxin Toxin
M8789_RS12270 (2459884) 2459884..2460135 - 252 WP_000584499.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
M8789_RS12275 (2460300) 2460300..2460380 - 81 WP_225539489.1 hypothetical protein -
M8789_RS12280 (2460408) 2460408..2461007 - 600 WP_000162810.1 DsbA family protein -
M8789_RS12285 (2461026) 2461026..2461388 - 363 WP_000819843.1 DUF4467 domain-containing protein -
M8789_RS12290 (2461643) 2461643..2462893 + 1251 WP_001012239.1 FemA/FemB family glycyltransferase FmhA -
M8789_RS12295 (2462990) 2462990..2463721 - 732 WP_000615461.1 amino acid ABC transporter ATP-binding protein -
M8789_RS12300 (2463718) 2463718..2464437 - 720 WP_000479579.1 amino acid ABC transporter permease -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-88)

Antitoxin

(1-74)


Sequences


Toxin        


Download         Length: 89 a.a.        Molecular weight: 10437.99 Da        Isoelectric Point: 10.0373

>T245597 WP_000113260.1 NZ_CP097571:c2459884-2459618 [Staphylococcus aureus]
MARLNITFSPQAFEDYKYFQQNDKKMVKKINELLKSIDRDGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp


Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9433.60 Da        Isoelectric Point: 4.3407

>AT245597 WP_000584499.1 NZ_CP097571:c2460135-2459884 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDMVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTITKD
IDV

Download         Length: 252 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB T1YB60

References