Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 6220731..6221326 Replicon chromosome
Accession NZ_CP097560
Organism Pseudomonas aeruginosa strain C4.2

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PAC42_RS29945 Protein ID WP_003113526.1
Coordinates 6221048..6221326 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag PAC42_RS29940 Protein ID WP_003099268.1
Coordinates 6220731..6221036 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAC42_RS29905 (PAC42_29825) 6215882..6216730 + 849 WP_003146058.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PAC42_RS29915 (PAC42_29835) 6216897..6217838 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PAC42_RS29920 (PAC42_29840) 6217955..6218569 + 615 WP_003099279.1 50S ribosomal protein L25/general stress protein Ctc -
PAC42_RS29925 (PAC42_29845) 6218611..6219195 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PAC42_RS29930 (PAC42_29850) 6219236..6220336 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
PAC42_RS29940 (PAC42_29860) 6220731..6221036 - 306 WP_003099268.1 HigA family addiction module antitoxin Antitoxin
PAC42_RS29945 (PAC42_29865) 6221048..6221326 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PAC42_RS29950 (PAC42_29870) 6221379..6221507 - 129 Protein_5921 integrase -
PAC42_RS29955 (PAC42_29875) 6221655..6223883 + 2229 WP_023108789.1 TonB-dependent receptor -
PAC42_RS29960 (PAC42_29880) 6223953..6224600 - 648 WP_003095021.1 carbonate dehydratase -
PAC42_RS29965 (PAC42_29885) 6224662..6225900 - 1239 WP_023108790.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(1-97)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T245587 WP_003113526.1 NZ_CP097560:c6221326-6221048 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11213.79 Da        Isoelectric Point: 5.0747

>AT245587 WP_003099268.1 NZ_CP097560:c6221036-6220731 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGKQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References