245580

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 6021672..6022267 Replicon chromosome
Accession NZ_CP097557
Organism Pseudomonas aeruginosa strain C1.3

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag PAC13_RS28985 Protein ID WP_003113526.1
Coordinates 6021989..6022267 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A0S3KUN4
Locus tag PAC13_RS28980 Protein ID WP_003111575.1
Coordinates 6021672..6021977 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PAC13_RS28945 (PAC13_28890) 6016824..6017672 + 849 WP_023092961.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
PAC13_RS28955 (PAC13_28900) 6017839..6018780 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
PAC13_RS28960 (PAC13_28905) 6018897..6019511 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
PAC13_RS28965 (PAC13_28910) 6019553..6020137 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
PAC13_RS28970 (PAC13_28915) 6020178..6021278 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
PAC13_RS28980 (PAC13_28925) 6021672..6021977 - 306 WP_003111575.1 HigA family addiction module antitoxin Antitoxin
PAC13_RS28985 (PAC13_28930) 6021989..6022267 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PAC13_RS28990 (PAC13_28935) 6022320..6022448 - 129 Protein_5733 integrase -
PAC13_RS28995 (PAC13_28940) 6022596..6024824 + 2229 WP_021264080.1 TonB-dependent receptor -
PAC13_RS29000 (PAC13_28945) 6024894..6025541 - 648 WP_003095021.1 carbonate dehydratase -
PAC13_RS29005 (PAC13_28950) 6025603..6026841 - 1239 WP_023092962.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10646.19 Da        Isoelectric Point: 7.8937

>T245580 WP_003113526.1 NZ_CP097557:c6022267-6021989 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

>T245580 NZ_CP097557:c6022267-6021989 [Pseudomonas aeruginosa]
ATGATTCTGACCTTTCGCTGCGACGAGACTCGTCAGCTTTTTGAGACGGGTCTTTCGAGGCGGTGGGGAGCGATCCTCAC
AGTCGCTACGCGTAAGCTCGCAATGCTTCATGCGGCTACGGAGCTTCGAGACTTGCGCTCTCCACCTGGAAACCGCTTGG
AGCCGTTGCAGGGAAAGCGGGCGGGCCAACATAGCATCAGGATCAATGACCAGTGGCGTGTCTGTTTCGTCTGGACGGAT
GCGGGTCCCGAAGAAGTCGAAATAGTTGATTACCACTGA

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11205.72 Da        Isoelectric Point: 4.4475

>AT245580 WP_003111575.1 NZ_CP097557:c6021977-6021672 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAQG

Download         Length: 306 bp

>AT245580 NZ_CP097557:c6021977-6021672 [Pseudomonas aeruginosa]
ATGGCTACCAATGGTATGCGCCCCATCCATCCTGGGGAAATATTGCGCGATGAGTTTCTGATGGAGTTGGATATCTCTCC
AGCTGCTCTAGCACGCGCTTTGAAAGTCTCCGCTCCGACAGTGAATGATATCGTTCGTGAGCAGCGTGGTATCTCCGCAG
ATATGGCGATTCGTCTGGGGCGTTACTTTGATACGTCCGCTCAGTTCTGGATGAATCTCCAGAGTGAGTACTCGTTAGCA
ACTGCTTATGCGGCGAATGGCGAGCAGATCGAACATGAGATTGAGCCGCTGCTTGCTCAGGGATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure
AlphaFold DB A0A0S3KUN4

References