Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5320468..5321063 Replicon chromosome
Accession NZ_CP097555
Organism Pseudomonas aeruginosa strain B1.2

Toxin (Protein)


Gene name higB Uniprot ID V6ALY3
Locus tag M8Z32_RS24760 Protein ID WP_003113526.1
Coordinates 5320785..5321063 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M8Z32_RS24755 Protein ID WP_003133769.1
Coordinates 5320468..5320773 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Z32_RS24725 (M8Z32_24700) 5315838..5316110 + 273 WP_071538125.1 DNA-binding protein -
M8Z32_RS24730 (M8Z32_24705) 5316168..5316749 + 582 WP_123903235.1 sce7726 family protein -
M8Z32_RS24735 (M8Z32_24710) 5316736..5317806 - 1071 WP_023098928.1 beta family protein -
M8Z32_RS24740 (M8Z32_24715) 5317796..5318632 - 837 WP_079387117.1 ImmA/IrrE family metallo-endopeptidase -
M8Z32_RS24745 (M8Z32_24720) 5318625..5319299 - 675 WP_023098926.1 N-acetyltransferase -
M8Z32_RS24750 (M8Z32_24725) 5319725..5320132 - 408 WP_049267485.1 hypothetical protein -
M8Z32_RS24755 (M8Z32_24730) 5320468..5320773 - 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
M8Z32_RS24760 (M8Z32_24735) 5320785..5321063 - 279 WP_003113526.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8Z32_RS24765 (M8Z32_24740) 5321116..5321244 - 129 Protein_4891 integrase -
M8Z32_RS24770 (M8Z32_24745) 5321392..5323620 + 2229 WP_043089846.1 TonB-dependent receptor -
M8Z32_RS24775 (M8Z32_24750) 5323690..5324337 - 648 WP_003095021.1 carbonate dehydratase -
M8Z32_RS24780 (M8Z32_24755) 5324399..5325637 - 1239 WP_014603324.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10614.13 Da        Isoelectric Point: 7.8937

>T245569 WP_003113526.1 NZ_CP097555:c5321063-5320785 [Pseudomonas aeruginosa]
VILTFRCDETRQLFETGLSRRWGAILTVATRKLAMLHAATELRDLRSPPGNRLEPLQGKRAGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT245569 WP_003133769.1 NZ_CP097555:c5320773-5320468 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V6ALY3

Antitoxin

Source ID Structure

References