Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4749913..4750613 Replicon chromosome
Accession NZ_CP097529
Organism Pseudomonas putida strain KT2440 isolate pSEVA631

Toxin (Protein)


Gene name mqsR Uniprot ID Q88F93
Locus tag M8Z99_RS22005 Protein ID WP_010954960.1
Coordinates 4750317..4750613 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID I7AUJ7
Locus tag M8Z99_RS22000 Protein ID WP_003254235.1
Coordinates 4749913..4750314 (-) Length 134 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Z99_RS21980 (M8Z99_21955) 4745047..4745868 - 822 WP_010954957.1 transporter substrate-binding domain-containing protein -
M8Z99_RS21985 (M8Z99_21960) 4745944..4746873 - 930 WP_010954958.1 FAD-binding protein -
M8Z99_RS21990 (M8Z99_21965) 4746874..4747623 - 750 WP_003254232.1 electron transfer flavoprotein subunit beta/FixA family protein -
M8Z99_RS21995 (M8Z99_21970) 4748159..4749841 + 1683 WP_010954959.1 electron transfer flavoprotein-ubiquinone oxidoreductase -
M8Z99_RS22000 (M8Z99_21975) 4749913..4750314 - 402 WP_003254235.1 type II toxin-antitoxin system MqsA family antitoxin Antitoxin
M8Z99_RS22005 (M8Z99_21980) 4750317..4750613 - 297 WP_010954960.1 type II toxin-antitoxin system MqsR family toxin Toxin
M8Z99_RS22010 (M8Z99_21985) 4750708..4752033 - 1326 WP_010954961.1 MFS transporter -
M8Z99_RS22015 (M8Z99_21990) 4752106..4752585 - 480 WP_010954962.1 hypothetical protein -
M8Z99_RS22020 (M8Z99_21995) 4752754..4753230 - 477 WP_010954963.1 sigma-70 family RNA polymerase sigma factor -
M8Z99_RS22025 (M8Z99_22000) 4753443..4754621 + 1179 WP_010954964.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(6-97)

Antitoxin

Cro/C1-type helix-turn-helix domain

(74-109)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11133.22 Da        Isoelectric Point: 10.2271

>T245547 WP_010954960.1 NZ_CP097529:c4750613-4750317 [Pseudomonas putida]
MEKRMPHCPLERVKALAAARRIRPTGAALKGAKALGMDFPGMLEVITSLKRTDFYKSMTSHIDHRVWQDVYRPLTAIGYV
YLKLSVVDDVLIVSFKEL

Download         Length: 297 bp

Antitoxin


Download         Length: 134 a.a.        Molecular weight: 14684.76 Da        Isoelectric Point: 4.9531

>AT245547 WP_003254235.1 NZ_CP097529:c4750314-4749913 [Pseudomonas putida]
MRCPICGGSELAPDIQGMPYSYKGEMTVIPEVSGDYCSACGECVLSHDEAMRVSHLMTAFERQVNANVVDPSFIASIRRK
FDLDQREAGEIFGGGVNAFSRYENGKTTPPVALVKLLKLLDRHPELFEEVRTA

Download         Length: 402 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q88F93

Antitoxin

Source ID Structure
AlphaFold DB I7AUJ7

References