Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 712823..713516 Replicon chromosome
Accession NZ_CP097426
Organism Escherichia coli strain C289

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag M8Y67_RS03475 Protein ID WP_000415584.1
Coordinates 712823..713119 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag M8Y67_RS03480 Protein ID WP_000650107.1
Coordinates 713121..713516 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y67_RS03440 (707911) 707911..708225 - 315 WP_000958598.1 putative quinol monooxygenase -
M8Y67_RS03445 (708256) 708256..708837 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
M8Y67_RS03450 (709156) 709156..709488 + 333 WP_000917684.1 DUF2645 family protein -
M8Y67_RS03455 (709534) 709534..710883 - 1350 WP_001618857.1 quorum sensing histidine kinase QseC -
M8Y67_RS03460 (710880) 710880..711539 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
M8Y67_RS03465 (711691) 711691..712083 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
M8Y67_RS03470 (712136) 712136..712618 + 483 WP_000183505.1 GyrI-like domain-containing protein -
M8Y67_RS03475 (712823) 712823..713119 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
M8Y67_RS03480 (713121) 713121..713516 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
M8Y67_RS03485 (713649) 713649..715256 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
M8Y67_RS03490 (715394) 715394..717652 + 2259 WP_049253102.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T245442 WP_000415584.1 NZ_CP097426:712823-713119 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT245442 WP_000650107.1 NZ_CP097426:713121-713516 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References