Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1173874..1174649 Replicon chromosome
Accession NZ_CP097423
Organism Klebsiella pneumoniae strain K153

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A1Q4Q548
Locus tag M8Y71_RS05730 Protein ID WP_004150910.1
Coordinates 1174164..1174649 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID W8UEW1
Locus tag M8Y71_RS05725 Protein ID WP_004150912.1
Coordinates 1173874..1174167 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y71_RS05705 (M8Y71_05705) 1169082..1169684 - 603 WP_002916735.1 short chain dehydrogenase -
M8Y71_RS05710 (M8Y71_05710) 1169782..1170693 + 912 WP_004188550.1 LysR family transcriptional regulator -
M8Y71_RS05715 (M8Y71_05715) 1170694..1171842 - 1149 WP_004150915.1 PLP-dependent aspartate aminotransferase family protein -
M8Y71_RS05720 (M8Y71_05720) 1171853..1173229 - 1377 WP_004217775.1 cystathionine beta-synthase -
M8Y71_RS05725 (M8Y71_05725) 1173874..1174167 + 294 WP_004150912.1 DUF1778 domain-containing protein Antitoxin
M8Y71_RS05730 (M8Y71_05730) 1174164..1174649 + 486 WP_004150910.1 GNAT family N-acetyltransferase Toxin
M8Y71_RS05735 (M8Y71_05735) 1175353..1175946 + 594 WP_004188553.1 hypothetical protein -
M8Y71_RS05740 (M8Y71_05740) 1176043..1176259 + 217 Protein_1107 transposase -
M8Y71_RS05745 (M8Y71_05745) 1176865..1177737 + 873 WP_004188557.1 ParA family protein -
M8Y71_RS05750 (M8Y71_05750) 1177737..1178120 + 384 WP_004150906.1 hypothetical protein -
M8Y71_RS05755 (M8Y71_05755) 1178113..1179480 + 1368 WP_004150905.1 SPI-7-type island replicative DNA helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 1176043..1176195 152


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-143)

Antitoxin

Vibrio phage ICP1, Orf50

(3-95)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17551.59 Da        Isoelectric Point: 8.8818

>T245428 WP_004150910.1 NZ_CP097423:1174164-1174649 [Klebsiella pneumoniae]
MISAPEPLHAGHILTPFCCGIDSMDHWLKQRAMKNQVTGASRTFVCCDDAKVMAYYSLASSAVTTNTAPGRFRRNMPAPI
PVVVLGRLAVDKSLHGKGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEARDFYLRVGFEPSPMDPMMLMVTLRDLVN
A

Download         Length: 486 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10901.46 Da        Isoelectric Point: 6.3783

>AT245428 WP_004150912.1 NZ_CP097423:1173874-1174167 [Klebsiella pneumoniae]
MPAANSMSIKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEE

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4Q548

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GVL4

References