Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1482528..1483174 Replicon chromosome
Accession NZ_CP097419
Organism Klebsiella pneumoniae strain K229

Toxin (Protein)


Gene name higB Uniprot ID W8UNE1
Locus tag M8Y66_RS07265 Protein ID WP_002920560.1
Coordinates 1482827..1483174 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag M8Y66_RS07260 Protein ID WP_002920557.1
Coordinates 1482528..1482827 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y66_RS07240 (M8Y66_07240) 1478734..1479492 - 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -
M8Y66_RS07245 (M8Y66_07245) 1479542..1480372 - 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
M8Y66_RS07250 (M8Y66_07250) 1480423..1480752 - 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
M8Y66_RS07255 (M8Y66_07255) 1480957..1482465 + 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
M8Y66_RS07260 (M8Y66_07260) 1482528..1482827 - 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
M8Y66_RS07265 (M8Y66_07265) 1482827..1483174 - 348 WP_002920560.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8Y66_RS07270 (M8Y66_07270) 1483350..1485797 - 2448 WP_002920561.1 glycogen phosphorylase -
M8Y66_RS07275 (M8Y66_07275) 1485815..1487248 - 1434 WP_002920564.1 glycogen synthase GlgA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13502.56 Da        Isoelectric Point: 6.2300

>T245410 WP_002920560.1 NZ_CP097419:c1483174-1482827 [Klebsiella pneumoniae]
MWDVETTDTFDAWFELQSRALKEDMLATMLILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRACFAFDPLRKAI
VLCVGNKDGMNEKRFYKEMITLADREFSQHLTKER

Download         Length: 348 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT245410 WP_002920557.1 NZ_CP097419:c1482827-1482528 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E1CBY5

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References