Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 2399894..2400583 Replicon chromosome
Accession NZ_CP097415
Organism Klebsiella pneumoniae strain K163

Toxin (Protein)


Gene name higB Uniprot ID A0A331C6E2
Locus tag M8Y70_RS11735 Protein ID WP_021469727.1
Coordinates 2399894..2400211 (+) Length 106 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A6B0N7G3
Locus tag M8Y70_RS11740 Protein ID WP_020804705.1
Coordinates 2400287..2400583 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8Y70_RS11705 (2395596) 2395596..2396105 + 510 WP_020802144.1 GNAT family N-acetyltransferase -
M8Y70_RS11710 (2396115) 2396115..2397041 + 927 WP_032435210.1 amino acid ABC transporter permease -
M8Y70_RS11715 (2397025) 2397025..2397804 + 780 WP_002906697.1 amino acid ABC transporter ATP-binding protein -
M8Y70_RS11720 (2397843) 2397843..2398694 + 852 WP_072198177.1 transporter substrate-binding domain-containing protein -
M8Y70_RS11725 (2398772) 2398772..2399389 + 618 WP_032425015.1 glutathione S-transferase family protein -
M8Y70_RS11730 (2399460) 2399460..2399687 + 228 WP_002906690.1 tautomerase PptA -
M8Y70_RS11735 (2399894) 2399894..2400211 + 318 WP_021469727.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8Y70_RS11740 (2400287) 2400287..2400583 + 297 WP_020804705.1 NadS family protein Antitoxin
M8Y70_RS11745 (2400662) 2400662..2401108 + 447 WP_032435212.1 hypothetical protein -
M8Y70_RS11750 (2401149) 2401149..2402765 - 1617 WP_004175961.1 carbohydrate porin -
M8Y70_RS11755 (2402809) 2402809..2404191 - 1383 WP_004151222.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(43-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-75)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12221.10 Da        Isoelectric Point: 10.2217

>T245399 WP_021469727.1 NZ_CP097415:2399894-2400211 [Klebsiella pneumoniae]
MLTFIELQGFSKRRQVLLQDDEFRAFQEILINDPEAGDTISGTGGFRKIRWSRPGMGKRGGVRVIYYNVTKKGRIYLALI
YPKNEQDELNQEQKKMLRQVADLIN

Download         Length: 318 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11057.93 Da        Isoelectric Point: 6.7277

>AT245399 WP_020804705.1 NZ_CP097415:2400287-2400583 [Klebsiella pneumoniae]
MKDELFADLLASAEEMVRIEKGEQMLMEQHVHTFSEIDVKAIREATGLKQQDFAAAVGVSYELVKSWETKRRHPTGAARK
LLLLLQGNPLIINLLKVV

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A331C6E2

Antitoxin

Source ID Structure
AlphaFold DB A0A6B0N7G3

References