Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/RelE-HTH
Location 25692..26366 Replicon plasmid pKPTCM-3
Accession NZ_CP097388
Organism Klebsiella pneumoniae strain KPTCM

Toxin (Protein)


Gene name higB Uniprot ID A0A5Q9LMS5
Locus tag M6G79_RS26585 Protein ID WP_032720638.1
Coordinates 25692..26015 (+) Length 108 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M6G79_RS26590 Protein ID WP_032720637.1
Coordinates 26064..26366 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M6G79_RS26560 (M6G79_26535) 20714..22117 - 1404 WP_001567368.1 ISNCY-like element ISKpn21 family transposase -
M6G79_RS26565 (M6G79_26540) 22229..23761 + 1533 WP_023288255.1 IS3-like element ISKpn38 family transposase -
M6G79_RS26570 (M6G79_26545) 24033..24635 + 603 Protein_27 transposase -
M6G79_RS26575 (M6G79_26550) 24704..25131 - 428 Protein_28 DNA-binding protein -
M6G79_RS26580 (M6G79_26555) 25109..25514 + 406 Protein_29 DUF4113 domain-containing protein -
M6G79_RS26585 (M6G79_26560) 25692..26015 + 324 WP_032720638.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M6G79_RS26590 (M6G79_26565) 26064..26366 + 303 WP_032720637.1 NadS family protein Antitoxin
M6G79_RS26595 (M6G79_26570) 26409..26576 - 168 WP_153591440.1 hypothetical protein -
M6G79_RS26600 (M6G79_26575) 26764..26970 - 207 WP_153591439.1 hypothetical protein -
M6G79_RS26605 (M6G79_26580) 26967..27350 - 384 WP_032720636.1 hypothetical protein -
M6G79_RS26610 (M6G79_26585) 27455..28027 - 573 WP_032720635.1 GNAT family N-acetyltransferase -
M6G79_RS26615 (M6G79_26590) 28029..28841 - 813 WP_223203129.1 TSUP family transporter -
M6G79_RS26620 (M6G79_26595) 28853..29773 - 921 WP_050548604.1 TauD/TfdA family dioxygenase -
M6G79_RS26625 (M6G79_26600) 30076..30570 - 495 WP_044266755.1 hypothetical protein -
M6G79_RS26630 (M6G79_26605) 30601..31173 - 573 WP_044266753.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid qnrB1 / dfrA14 - 1..116556 116556


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(45-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(39-83)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12372.29 Da        Isoelectric Point: 9.6240

>T245372 WP_032720638.1 NZ_CP097388:25692-26015 [Klebsiella pneumoniae]
MNYLEFVETSAFSGLRKELMDDDEFRELQTYLLEAHDRGDTISHTGGCRKIRWGRPGMGKRGGVRVIYYVRLASGRLYLL
LIYPKNAKDELSEKEKAVMKALTQQLK

Download         Length: 324 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11211.12 Da        Isoelectric Point: 7.3611

>AT245372 WP_032720637.1 NZ_CP097388:26064-26366 [Klebsiella pneumoniae]
MEKKLFDALISSMEEMVAIENGQIQPAAEQVHRHTLPDVKAIRKHAGMKQAEFAEVVGASVDLVRSWEQQRRVPSGIALK
MLCLIEREPALINTLRGIHV

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q9LMS5

Antitoxin

Source ID Structure

References