245356

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 5890092..5890687 Replicon chromosome
Accession NZ_CP097383
Organism Pseudomonas aeruginosa strain L00-a

Toxin (Protein)


Gene name higB Uniprot ID A0A9E8L6K5
Locus tag M8G39_RS27875 Protein ID WP_071534386.1
Coordinates 5890409..5890687 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M8G39_RS27870 Protein ID WP_003133769.1
Coordinates 5890092..5890397 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8G39_RS27835 (M8G39_27835) 5885233..5886081 + 849 WP_009878189.1 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase -
M8G39_RS27845 (M8G39_27845) 5886248..5887189 + 942 WP_003099281.1 ribose-phosphate pyrophosphokinase -
M8G39_RS27850 (M8G39_27850) 5887306..5887920 + 615 WP_003095013.1 50S ribosomal protein L25/general stress protein Ctc -
M8G39_RS27855 (M8G39_27855) 5887962..5888546 + 585 WP_003099278.1 aminoacyl-tRNA hydrolase -
M8G39_RS27860 (M8G39_27860) 5888587..5889687 + 1101 WP_003099270.1 redox-regulated ATPase YchF -
M8G39_RS27870 (M8G39_27870) 5890092..5890397 - 306 WP_003133769.1 HigA family addiction module antitoxin Antitoxin
M8G39_RS27875 (M8G39_27875) 5890409..5890687 - 279 WP_071534386.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8G39_RS27880 (M8G39_27880) 5890740..5890862 - 123 Protein_5521 integrase -
M8G39_RS27885 (M8G39_27885) 5891010..5893238 + 2229 WP_034005476.1 TonB-dependent receptor -
M8G39_RS27890 (M8G39_27890) 5893308..5893955 - 648 WP_003095021.1 carbonate dehydratase -
M8G39_RS27895 (M8G39_27895) 5894017..5895255 - 1239 WP_003111578.1 C69 family dipeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(5-92)

Antitoxin

Toxin-antitoxin system, antidote protein, HigA

(6-82)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10698.23 Da        Isoelectric Point: 7.9184

>T245356 WP_071534386.1 NZ_CP097383:c5890687-5890409 [Pseudomonas aeruginosa]
MILTFRCDETRQLFETGLSRRWGAILTVATRKLAMHHAATELRDLRSPPGNRLEPLQGKRVGQHSIRINDQWRVCFVWTD
AGPEEVEIVDYH

Download         Length: 279 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11214.73 Da        Isoelectric Point: 4.6081

>AT245356 WP_003133769.1 NZ_CP097383:c5890397-5890092 [Pseudomonas aeruginosa]
MATNGMRPIHPGEILRDEFLMELDISPAALARALKVSAPTVNDIVREQRGISADMAIRLGRYFDTSAQFWMNLQSEYSLA
TAYAANGEQIEHEIEPLLAHG

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References