Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 90262..90913 Replicon plasmid pP14-114
Accession NZ_CP097382
Organism Providencia stuartii strain P14

Toxin (Protein)


Gene name higB Uniprot ID A0A857SB97
Locus tag M8G38_RS21785 Protein ID WP_042847389.1
Coordinates 90262..90612 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag M8G38_RS21790 Protein ID WP_249890904.1
Coordinates 90614..90913 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M8G38_RS21770 (M8G38_21770) 86072..87022 - 951 WP_249890902.1 AEC family transporter -
M8G38_RS21775 (M8G38_21775) 87091..88716 - 1626 WP_249890903.1 benzoylformate decarboxylase -
M8G38_RS21780 (M8G38_21780) 89090..89995 - 906 WP_159242422.1 IS481 family transposase -
M8G38_RS21785 (M8G38_21785) 90262..90612 + 351 WP_042847389.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M8G38_RS21790 (M8G38_21790) 90614..90913 + 300 WP_249890904.1 XRE family transcriptional regulator Antitoxin
M8G38_RS21795 (M8G38_21795) 91096..92397 - 1302 WP_282562167.1 hypothetical protein -
M8G38_RS21800 (M8G38_21800) 92529..93728 - 1200 WP_249890886.1 IS91 family transposase -
M8G38_RS21805 (M8G38_21805) 93831..94079 - 249 WP_249890906.1 hypothetical protein -
M8G38_RS21810 (M8G38_21810) 94232..94969 - 738 WP_249890907.1 hypothetical protein -
M8G38_RS21815 (M8G38_21815) 94991..95179 - 189 WP_249890908.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..114876 114876
- flank IS/Tn - - 84990..85937 947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(32-84)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13437.50 Da        Isoelectric Point: 5.2661

>T245349 WP_042847389.1 NZ_CP097382:90262-90612 [Providencia stuartii]
MWEILTRDLFDSWFEEQNEETQIEVLAVLMILREDGPNLGRPQVDTLKGSQFPNMKELRIQVGGHPIRACFAFDPIRRGI
VLCAGDKKGKDETRFYKKLIKMADAEYAAHLLEQEK

Download         Length: 351 bp

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10909.63 Da        Isoelectric Point: 9.7246

>AT245349 WP_249890904.1 NZ_CP097382:90614-90913 [Providencia stuartii]
MSTLDKLLAKQSPEARAQIEARAEEIRREITLAKIREELNLSQTELAQSLGVSQPSIAKLEKVDNDPKLSTLKRYIKALG
GELSIDVTLPNGKRIGLSL

Download         Length: 300 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A857SB97

Antitoxin

Source ID Structure

References