Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) prlF-yhaV (relBE)/YhaV-PrlF
Location 663152..663951 Replicon chromosome
Accession NZ_CP097370
Organism Escherichia coli strain AGR5151

Toxin (Protein)


Gene name yhaV Uniprot ID S1NYM6
Locus tag M7748_RS03230 Protein ID WP_000347251.1
Coordinates 663152..663616 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name prlF Uniprot ID S1PPV5
Locus tag M7748_RS03235 Protein ID WP_001296435.1
Coordinates 663616..663951 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7748_RS03200 (658153) 658153..658587 - 435 WP_000948824.1 PTS galactosamine/N-acetylgalactosamine transporter subunit IIA -
M7748_RS03205 (658605) 658605..659483 - 879 WP_001295548.1 PTS N-acetylgalactosamine transporter subunit IID -
M7748_RS03210 (659473) 659473..660252 - 780 WP_000406214.1 PTS N-acetylgalactosamine transporter subunit IIC -
M7748_RS03215 (660263) 660263..660736 - 474 WP_001295547.1 PTS N-acetylgalactosamine transporter subunit IIB -
M7748_RS03220 (660759) 660759..662039 - 1281 WP_000681950.1 tagatose-bisphosphate aldolase subunit KbaZ -
M7748_RS03225 (662288) 662288..663097 + 810 WP_000072187.1 aga operon transcriptional regulator AgaR -
M7748_RS03230 (663152) 663152..663616 - 465 WP_000347251.1 type II toxin-antitoxin system ribonuclease toxin YhaV Toxin
M7748_RS03235 (663616) 663616..663951 - 336 WP_001296435.1 type II toxin-antitoxin system antitoxin PrlF Antitoxin
M7748_RS03240 (664100) 664100..665671 - 1572 WP_001273763.1 galactarate dehydratase -
M7748_RS03245 (666046) 666046..667380 + 1335 WP_000599651.1 galactarate/glucarate/glycerate transporter GarP -
M7748_RS03250 (667396) 667396..668166 + 771 WP_001058227.1 2-dehydro-3-deoxyglucarate aldolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin endonuclease, YhaV

(12-150)

Antitoxin

PrlF antitoxin

(14-110)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 17777.14 Da        Isoelectric Point: 9.4947

>T245316 WP_000347251.1 NZ_CP097370:c663616-663152 [Escherichia coli]
MDFPQRVNGWALYAHPCFQETYDALVAEVEALKGKDPENYQRKAATKLLAVVHKVIEEHITVNPSSPAFRHGKSLGSGKN
KDWSRVKFGAGRYRLFFRYSEKEKVIILGWMNDENTLRTYGKKTDAYTVFSKMLKRGHPPADWESLTQETEENH

Download         Length: 465 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12321.92 Da        Isoelectric Point: 4.5392

>AT245316 WP_001296435.1 NZ_CP097370:c663951-663616 [Escherichia coli]
MPANARSNAVLTTESKVTIRGQTTIPAPVREALKLKPGLDSIHYEILPGGQVFMCRLGDEQEDHTMNAFLRFLDADIQNN
PQKTRPFDIQQGKKLVAGMDVNIDDEIGDDE

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CJ20

Antitoxin

Source ID Structure
AlphaFold DB S1PPV5

References