245314

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) HipBST/HipA(toxin)
Location 246080..247398 Replicon chromosome
Accession NZ_CP097370
Organism Escherichia coli strain AGR5151

Toxin (Protein)


Gene name HipT Uniprot ID F4T5A3
Locus tag M7748_RS01145 Protein ID WP_001262467.1
Coordinates 246391..247398 (+) Length 336 a.a.

Antitoxin (Protein)


Gene name HipS Uniprot ID F4T5A4
Locus tag M7748_RS01140 Protein ID WP_001312177.1
Coordinates 246080..246391 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7748_RS01115 (241612) 241612..242631 + 1020 WP_000938855.1 dipeptide ABC transporter permease DppB -
M7748_RS01120 (242641) 242641..243543 + 903 WP_000084677.1 dipeptide ABC transporter permease DppC -
M7748_RS01125 (243554) 243554..244537 + 984 WP_001196477.1 dipeptide ABC transporter ATP-binding protein -
M7748_RS01130 (244534) 244534..245547 + 1014 WP_000103572.1 dipeptide ABC transporter ATP-binding subunit DppF -
M7748_RS01135 (245772) 245772..246095 + 324 WP_000563102.1 helix-turn-helix transcriptional regulator -
M7748_RS01140 (246080) 246080..246391 + 312 WP_001312177.1 HipA N-terminal domain-containing protein Antitoxin
M7748_RS01145 (246391) 246391..247398 + 1008 WP_001262467.1 HipA domain-containing protein Toxin
M7748_RS01150 (247415) 247415..248686 - 1272 WP_001545666.1 amino acid permease -
- (249048) 249048..249113 - 66 NuclAT_27 - -
- (249048) 249048..249113 - 66 NuclAT_27 - -
- (249048) 249048..249113 - 66 NuclAT_27 - -
- (249048) 249048..249113 - 66 NuclAT_27 - -
M7748_RS01155 (249162) 249162..249269 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
- (249531) 249531..249588 - 58 NuclAT_26 - -
- (249531) 249531..249588 - 58 NuclAT_26 - -
- (249531) 249531..249588 - 58 NuclAT_26 - -
- (249531) 249531..249588 - 58 NuclAT_26 - -
M7748_RS01160 (249645) 249645..249752 + 108 WP_000170748.1 type I toxin-antitoxin system toxin Ldr family protein -
M7748_RS01165 (250128) 250128..250235 + 108 WP_001295224.1 type I toxin-antitoxin system toxin Ldr family protein -
M7748_RS01170 (250321) 250321..252000 - 1680 Protein_231 cellulose biosynthesis protein BcsG -
M7748_RS01175 (251997) 251997..252188 - 192 WP_000988308.1 cellulose biosynthesis protein BcsF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(56-302)

Antitoxin

HipA, N-terminal subdomain 1

(6-98)


Sequences

Toxin        


Download         Length: 336 a.a.        Molecular weight: 38320.60 Da        Isoelectric Point: 5.5965

>T245314 WP_001262467.1 NZ_CP097370:246391-247398 [Escherichia coli]
MANCRILLTPLNERDEQRGYSTQGLKRLSGTAKLTPRLGFTRTQFVQELPRQQKGMSISGYQPKLQLVLDEGEFRVVDHQ
GNFILKPSPADFPGLAENEHATMTLMSRLGFDVPVHGLLSFAPQSEEELEYAFVIRRYDRDNKGLPVHQEQLDGAMQIMD
KYGKTGNDNEQYVSYETLARFLVAHVNDNIAFKIDLFRRIVYAWLLGNNDMHLRNFGLVYSDGLTPALAPVYDFVSVAPY
PEYFHSNYLALPLLTREEGGRELAPGFHSDYGEYIGQDFLLLGESMGLAPRLLEKLFQDIRKENAIVMETYEQSFMTQDH
IQAVLQCYRHRLGLL

Download         Length: 1008 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11821.47 Da        Isoelectric Point: 6.0609

>AT245314 WP_001312177.1 NZ_CP097370:246080-246391 [Escherichia coli]
MHRRVKVLLYGQVVGELSQNDSGFLFQYAPDYHGPAISISLPVAQRQFPSEMLHPYFASLAPEGWLRQRYSQIQHRDEND
LLGMLIDNGKNLLGAIQILPWEE

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3K2ZTB5

Antitoxin

Source ID Structure
AlphaFold DB A0A3L3HKE2

References