245293

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1951988..1952490 Replicon chromosome
Accession NZ_CP097367
Organism Escherichia coli strain AGR6128

Toxin (Protein)


Gene name yoeB Uniprot ID S1P977
Locus tag M7747_RS09245 Protein ID WP_000767822.1
Coordinates 1952236..1952490 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag M7747_RS09240 Protein ID WP_001259255.1
Coordinates 1951988..1952239 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M7747_RS09215 (1947166) 1947166..1948233 - 1068 WP_000080105.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
M7747_RS09220 (1948233) 1948233..1949303 - 1071 WP_000108941.1 histidinol-phosphate transaminase -
M7747_RS09225 (1949300) 1949300..1950604 - 1305 WP_001546022.1 histidinol dehydrogenase -
M7747_RS09230 (1950610) 1950610..1951509 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
M7747_RS09235 (1951655) 1951655..1951705 - 51 WP_001364200.1 his operon leader peptide -
M7747_RS09240 (1951988) 1951988..1952239 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
M7747_RS09245 (1952236) 1952236..1952490 + 255 WP_000767822.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
M7747_RS09250 (1952573) 1952573..1953397 + 825 WP_000754737.1 SDR family oxidoreductase -
M7747_RS09255 (1953443) 1953443..1954372 + 930 WP_000803366.1 LysR substrate-binding domain-containing protein -
M7747_RS09260 (1954587) 1954587..1954649 + 63 WP_010723108.1 membrane protein YoeI -
M7747_RS09265 (1954639) 1954639..1955997 + 1359 WP_000019194.1 putrescine/proton symporter PlaP -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T245293 WP_000767822.1 NZ_CP097367:1952236-1952490 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINEIIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT245293 WP_001259255.1 NZ_CP097367:1951988-1952239 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1P977

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References